Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys.

American Journal of Physiology. Heart and Circulatory Physiology
Denis BabiciStephen F Vatner

Abstract

Protection against increased vascular stiffness in young women is lost after menopause. However, little is known about vascular stiffness in older, premenopausal females, because most of the prior work has been conducted in rodents, which live for only 1-3 yr and do not go through menopause. The goal of the current investigation was to quantitate differences in stiffness down the aortic tree and the mechanisms mediating those differences in older, premenopausal (24 ± 0.7 yr) versus young adult (7 ± 0.7 yr) female nonhuman primates. Aortic stiffness (β), calculated from direct and continuous measurements of aortic diameter and pressure in chronically instrumented, conscious macaque monkeys, increased 2.5-fold in the thoracic aorta and fivefold in the abdominal aorta in old premenopausal monkeys. The aortic histological mechanisms mediating increased vascular stiffness, i.e., collagen/elastin ratio, elastin, and collagen disarray, and the number of breaks in elastin and collagen fibers were greater in the old premenopausal versus young monkeys and greater in the abdominal versus the thoracic aorta and greatest in the iliac artery. In addition, more immature and less cross-linked fibers of collagen were found in the aortas of youn...Continue Reading

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Citations

Jul 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Francisco I Ramirez-PerezJaume Padilla
Dec 11, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Francisco I Ramirez-PerezGuido Lastra

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