PMID: 3057362Dec 1, 1988Paper

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview

Mutation Research
S De Flora, C Ramel

Abstract

The mechanisms of action of inhibitors of mutagenesis and carcinogenesis are reviewed in the light of our present knowledge. The identified mechanisms are classified into several categories and sub-categories, depending on the stage of intervention in the mutagenesis and carcinogenesis processes, and on the patterns of modulation of the host defense devices. Although a number of the known mechanisms fit into the proposed scheme, the available information on these problems is still fragmentary, and often inhibitors act through multiple mechanisms or can interact with other inhibitors. Moreover, due to the double-edged nature of many protective factors of the organism, and to the wide array of biological properties displayed by several inhibitors, the beneficial effects are in many instances counter-balanced by adverse reactions. Nevertheless, the present data-base on mechanisms of inhibitors, which is expected to grow rapidly in the near future, provides an extremely useful scientific premise for the primary prevention of mutation-related diseases. In this prospect, the elucidation of the underlying mechanisms complements the results emerging from the monitoring of protective end-points in mutagenicity and carcinogenicity test s...Continue Reading

References

Jul 12, 1975·Lancet·P CorreaM Archer
Mar 19, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·D SchmählB Diehl
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M S MeynW Troll
Feb 1, 1977·Journal of the National Cancer Institute·L K Lam, L W Wattenberg
Dec 17, 1985·Biochemical and Biophysical Research Communications·J D ChangA R Kennedy
Jun 1, 1986·The Journal of Clinical Investigation·F L PetrilliS De Flora
Feb 1, 1988·Mutation Research·M TakeuchiT Kada
Jan 1, 1985·Advances in Cancer Research·R J North
Dec 1, 1988·Mutation Research·D A BoothmanA B Pardee
Jan 25, 1985·Science·P A Cerutti
Jan 1, 1985·Annual Review of Nutrition·E S FialaJ H Weisburger
Dec 1, 1988·Mutation Research·T Gichner, J Velemínský
Dec 1, 1988·Mutation Research·H HayatsuT Negishi
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·K C FlintN M Johnson
Jan 1, 1988·Mutation Research·T Gichner, J Velemínský
Apr 18, 1987·Medicina clínica·J L Alfonso Sánchez
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
Sep 1, 1987·Mutation Research·T Nunoshiba, H Nishioka
Dec 1, 1987·Pathology, Research and Practice·F Marks
Jan 16, 1987·Science·J M Bishop
Mar 1, 1987·Journal of Cellular Biochemistry·I B Weinstein
Apr 17, 1987·Science·B N AmesL S Gold

❮ Previous
Next ❯

Citations

Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Roumen M BalanskySilvio De Flora
Dec 1, 1994·Journal of Cellular Biochemistry·R M BalanskyS De Flora
Jan 1, 1994·Journal of Cellular Biochemistry. Supplement·G J KelloffC C Sigman
Jan 1, 1990·Teratogenesis, Carcinogenesis, and Mutagenesis·S De Flora
Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·S GhaskadbiV G Vaidya
Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·Z L WuW Z Whong
Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·P K Khan, S P Sinha
Jan 1, 1995·Teratogenesis, Carcinogenesis, and Mutagenesis·A Czyzewska, L Mazur
Jan 1, 1995·International Archives of Occupational and Environmental Health·M P DeMéoG Duménil
Feb 22, 2001·Bulletin of Experimental Biology and Medicine·E G BelogolovskayaY N Zubtsov
Jun 20, 2007·Plant Foods for Human Nutrition·María Elena Santos-CervantesFrancisco Delgado-Vargas
Oct 1, 1994·Clinical Biochemistry·B Stavric
Jun 1, 1992·Mutation Research·H E BrockmanM D Waters
Jun 1, 1992·Mutation Research·E Gebhart
Jun 1, 1992·Mutation Research·C Ramel, J Magnusson
Jun 1, 1992·Mutation Research·L A MitscherG Stewart
May 1, 1994·Mutation Research·L R Ferguson
Feb 19, 1996·Mutation Research·M D WatersS De Flora
Feb 19, 1996·Mutation Research·L A MitscherD M Shankel
Sep 23, 1996·Mutation Research·D M SalvadoriA T Natarajan
Jan 1, 1994·Advances in Enzyme Regulation· Antipenko AYe, Y N Antipenko
Jan 1, 1990·Mutation Research·M D WatersH E Brockman
Sep 1, 1992·Mutation Research·T Neudecker
Jun 1, 1994·Mutation Research·D Chorvatovicová
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Stavric
Oct 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A GhoshG Talukder
Nov 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Aruna, V M Sivaramakrishnan
Jun 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K V BalaK P Rao
Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Bose, S P Sinha
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T DasG Talukder
Aug 23, 1996·Cancer Letters·K GasiorowskiA Kozubek
Jan 1, 2004·Environmental Toxicology and Pharmacology·Usha R AcharyaRashmi R Tripathy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.