PMID: 8592118Feb 1, 1996Paper

Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: role of reverse sodium-calcium exchange

Journal of Neurochemistry
E J LehningR M LoPachin

Abstract

To investigate the route of axonal Ca2+ entry during anoxia, electron probe x-ray microanalysis was used to measure elemental composition of anoxic tibial nerve myelinated axons after in vitro experimental procedures that modify transaxolemmal Na+ and Ca2+ movements. Perfusion of nerve segments with zero-Na+/Li(+)-substituted medium and Na+ channel blockade by tetrodotoxin (1 microM) prevented anoxia-induced increases in Na and Ca concentrations of axoplasm and mitochondria. Incubation with a zero-Ca2+/EGTA perfusate impeded axonal and mitochondrial Ca accumulation during anoxia but did not affect characteristic Na and K responses. Inhibition of Na(+)-Ca2+ exchange with bepridil (50 microM) reduced significantly the Ca content of anoxic axons although mitochondrial Ca remained at anoxic levels. Nifedipine (10 microM), an L-type Ca2+ channel blocker, did not alter anoxia-induced changes in axonal Na, Ca, and K. Exposure of normoxic control nerves to tetrodotoxin, bepridil, or nifedipine did not affect axonal elemental composition, whereas both zero-Ca2+ and zero-Na+ solutions altered normal elemental content characteristically and significantly. The findings of this study suggest that during anoxia, Na+ enters axons via voltage-...Continue Reading

Citations

Jul 30, 2014·Diabetes/metabolism Research and Reviews·Natalie KwaiArun V Krishnan
Sep 15, 2015·The Journal of Physiology·Zhongsheng Zhang, Gavriel David
Jan 9, 2007·Muscle & Nerve·Nicolae PetrescuPeter K Stys
Mar 14, 2018·The Journal of Clinical Investigation·Nirupa D JayarajDaniela M Menichella
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Oct 19, 2011·Journal of the Peripheral Nervous System : JPNS·Susanna B ParkMatthew C Kiernan
Sep 26, 2012·Diabetes/metabolism Research and Reviews·Ria ArnoldArun V Krishnan
Jan 3, 2013·Annals of Neurology·Anna-Karin PerssonStephen G Waxman
Jan 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P K Stys
Jan 31, 2003·Annals of Neurology·Raju KapoorKenneth J Smith
Feb 13, 2001·Journal of Neurophysiology·A M BrownB R Ransom
Nov 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Catharina G FaberStephen G Waxman
Jul 20, 2000·Journal of Neuropathology and Experimental Neurology·M S WangJ D Glass
Dec 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael P KurnellasStella Elkabes
Sep 29, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Georgia MandolesiGian Michele Ratto
Apr 1, 1997·Toxicology and Applied Pharmacology·R M LoPachin, E J Lehning

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