Mechanisms of innate immune evasion in re-emerging RNA viruses

Current Opinion in Virology
Daphne Y Ma, Mehul S Suthar

Abstract

Recent outbreaks of Ebola, West Nile, Chikungunya, Middle Eastern Respiratory and other emerging/re-emerging RNA viruses continue to highlight the need to further understand the virus-host interactions that govern disease severity and infection outcome. As part of the early host antiviral defense, the innate immune system mediates pathogen recognition and initiation of potent antiviral programs that serve to limit virus replication, limit virus spread and activate adaptive immune responses. Concordantly, viral pathogens have evolved several strategies to counteract pathogen recognition and cell-intrinsic antiviral responses. In this review, we highlight the major mechanisms of innate immune evasion by emerging and re-emerging RNA viruses, focusing on pathogens that pose significant risk to public health.

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Citations

May 26, 2015·Current Opinion in Virology·Michael Gale, Curt M Horvath
Apr 21, 2016·Cellular and Molecular Life Sciences : CMLS·Yuanwu LiuXiangdong Li
Nov 18, 2016·Virologica Sinica·Yun-Jia NingHualin Wang
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Methods Mentioned

BETA
ubiquitination
nuclear translocation
transfection

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