PMID: 11922076Apr 2, 2002Paper

Mechanisms of integrin-mediated virus attachment and internalization process

Critical Reviews in Immunology
K TriantafilouM Triantafilou

Abstract

Viruses that propagate within vertebrate hosts have adapted many strategies to infect host cells. One of the first steps in a viral infection is the binding of the virus to cell surface molecules. This interaction between a virus and its receptors plays a key role in the multiplication cycle. Entry of viruses into cells is a complex, multistep process, and for several viruses, cell attachment and internalization are distinct steps. A number of virus receptors have been identified; a common family of viral receptors is the integrin family. Integrins are a widely expressed family of cell adhesion receptors, by which cells attach to extracellular matrices; they also mediate important cell-cell adhesion events. Integrins are involved in a number of tissue remodeling events, including embryogenesis, angiogenesis, wound repair, and bone resorption. In addition, several integrins are used by manyviruses in theirinfectious cycle. Virus-integrin interactions maybe more complex than previously thought because several viruses can interact with unique integrin regions or can activate distinct signaling pathways. This article will discuss the strategies devised by many viruses in their integrin-mediated attachment or cell entry.

Citations

Aug 2, 2003·Current Opinion in Cell Biology·Lucas Pelkmans, Ari Helenius
Dec 9, 2010·The Journal of Biological Chemistry·Fiona E FlemingBarbara S Coulson
Feb 14, 2003·Journal of Virology·Fu-Zhang WangBala Chandran
Apr 26, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mubeen JafriGreg Tiao
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Krishna KadaveruMartin R Schiller
Jul 20, 2006·Journal of Pharmaceutical Sciences·Alison L DunehooTeruna J Siahaan
Dec 23, 2009·International Journal of Cancer. Journal International Du Cancer·Donatella D'EliseoFrancesca Velotti
May 29, 2004·Trends in Microbiology·Susana López, Carlos F Arias
Jan 26, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·O H P Ramos, H S Selistre-de-Araujo
May 10, 2013·The Journal of General Virology·Katja SchmidtMartin H Groschup
Nov 29, 2005·Biochemical and Biophysical Research Communications·Dan Lei MouXue Fan Bai
Jul 28, 2007·Virology·Deng-Feng LiXun Xu
Aug 30, 2006·Advances in Immunology·Donald E StauntonW Michael Gallatin
Jul 8, 2017·International Journal of Molecular Sciences·Xiaoqian TangWenbin Zhan
Feb 4, 2005·Gene Therapy·B H Shen, T W Hermiston
Aug 28, 2004·Journal of Medical Virology·George OrthopoulosMartha Triantafilou
Jun 15, 2007·Chemistry : a European Journal·Carsten SchmuckThomas Schrader
Aug 18, 2017·Journal of Virology·David PlotnikShiu-Lok Hu
Apr 22, 2005·The Journal of Biological Chemistry·Marguerite S BuzzaPhillip I Bird
Aug 18, 2006·Biological Chemistry·Marguerite S Buzza, Phillip I Bird
Sep 1, 2015·Archives of Virology·Hosni A M HusseinShaw M Akula
May 23, 2014·Journal of Biosciences·Jing-Yan ZhangJie Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
C A GuerreroC F Arias
Expert Review of Clinical Immunology
Jean Frédéric Colombel, Laurent Peyrin-Biroulet
© 2022 Meta ULC. All rights reserved