Mechanisms of intravenous immunoglobulin action in the treatment of autoimmune disorders

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Claire LarrocheLuc Mouthon

Abstract

Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human immunoglobulin (Ig) G obtained from pools of blood from more than 1000 healthy donors, and exert immunomodulatory effects in autoantibody-mediated and T-cell-mediated autoimmune disorders and systemic inflammatory diseases. IVIg mechanisms of action in autoimmune diseases have been extensively analysed during the last 15 years and include the following: (i) interaction of the IgG Fc fragment with Fc receptors on leucocytes and endothelial cells; (ii) interaction of infused IgG with complement proteins; (iii) monocyte and lymphocyte modulation of synthesis and release of cytokines and cytokine antagonists; (iv) modulation of cell proliferation and reparation; (v) neutralisation of circulating autoantibodies; (vi) selection of immune repertoires; and (vii) interaction with other cell-surface molecules on T and B lymphocytes.

References

Jul 1, 1992·European Journal of Immunology·G DietrichM D Kazatchkine
Jun 1, 1991·Blood Reviews·S J Rosenfeld, N S Young
Jan 9, 1992·The New England Journal of Medicine·J M Dwyer
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F VarelaA Coutinho
May 8, 1986·The New England Journal of Medicine·S B ClarksonJ C Unkeless
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y SultanM D Kazatchkine
Mar 30, 1984·The American Journal of Medicine·D H Bing
May 1, 1995·Stem Cells·K BendtzenM Svenson
Jan 1, 1995·Arthritis and Rheumatism·M Qi, J A Schifferli
Jan 1, 1994·Immunologic Research·S Okitsu-NegishiT Abe
Jun 1, 1994·Immunological Reviews·U AnderssonJ Andersson
Jun 1, 1994·Immunological Reviews·W P Arend, D Y Leung
Sep 1, 1993·Journal of Clinical Immunology·Z D LingD S Matheson
Dec 30, 1993·The New England Journal of Medicine·M C DalakasS McCrosky
Aug 1, 1996·The Journal of Urology·E Y ChengW E Kaplan
Apr 1, 1997·Clinical Immunology and Immunopathology·J F ModianoE W Gelfand
May 1, 1997·Annals of Internal Medicine·M C Dalakas
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·A PashovM D Kazatchkine

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Citations

Aug 2, 2006·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Kimberly Duff
Jun 21, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Cynthia M MagroPatrick Ross
Jul 10, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Heinz Wiendl, Reinhard Hohlfeld
Dec 14, 2007·Expert Opinion on Therapeutic Targets·Thiruma V ArumugamMark P Mattson
Aug 10, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Éric AubinRenée Bazin
Apr 14, 2009·Annales de dermatologie et de vénéréologie·L LopezG Guillet
Jan 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jimie AndersonTerez Shea-Donohue
Nov 16, 2004·Journal of Dermatological Science·Jing Wang, Xuejun Zhu
Sep 21, 2005·International Journal of Pharmaceutics·Rong Deng, Joseph P Balthasar
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nicholas R BannerAsghar Khaghani
Jun 26, 2003·Allergy·H U Simon, P J Späth
Aug 10, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Louise LohseLis Eriksen
Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Martine Bruley-RossetDominique Bourel

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