Mechanisms of kinin B1-receptor-induced hypotension in the anesthetized dog

Journal of Cardiovascular Pharmacology
D LamontagneR Nadeau

Abstract

Our study was performed to investigate the mechanism underlying the phypotensive effect of kinin B1-receptor activation with des-Arg9-bradykinin (des-Arg9-BK), in comparison with B2-receptor activation with bradykinin (BK), in anesthetized dogs. Bolus intravenous and intraarterial injections of both kinins were compared. BK (0.6 microgram/kg) produced a transient hypotension of the same magnitude, regardless of the route of administration (from 110 +/- 6 mm Hg to 66 +/- 6 mm Hg, or -41 +/- 5%). In contrast, intraarterial injection of des-Arg9-BK (0.6 microgram/kg) induced a weaker hypotension compared with its intravenous injection (-27 +/- 2% vs. -39 +/- 3%, p < 0.05). The hypotension induced by both kinins was accompanied by increases in heart rate, maximum left ventricular dP/dt, and aortic blood flow, suggesting a reduction in peripheral resistance. The positive inotropic and chronotropic effects of BK and des-Arg9-BK were found to be mediated by the sympathetic nervous system, because they were abolished by propranolol. The hypotension induced by intravenous and intraarterial injections of BK and intravenous injections of des-Arg9-BK was only slightly reduced after nitric oxide (NO) synthase inhibition with NG-nitro-L-argi...Continue Reading

References

Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
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Citations

Nov 8, 2001·European Journal of Pharmacology·R CoutureF Cloutier
Jan 11, 2003·British Journal of Pharmacology·Rose Mari J ViannaRéjean Couture
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Masao KakokiOliver Smithies
Sep 24, 2013·Acta Physiologica Hungarica·Z KaygısızE Kılınç
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C TschöpeT Walther
Nov 1, 2020·Pharmaceuticals·Suhail HamidNour-Eddine Rhaleb

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