Mechanisms of L-NG nitroarginine/indomethacin-resistant relaxation in bovine and porcine coronary arteries

British Journal of Pharmacology
W F GraierG M Kostner

Abstract

1. Coronary arteries from bovines (BCA) and pigs (PCA) were used for measuring endothelium-dependent relaxation in the presence of L-NG nitroarginine and indomethacin. As some compounds tested have been found to have an inhibitory effect on autacoid-activated endothelial Ca2+ signalling, endothelium-dependent relaxation was initiated with the Ca2+ ionophore A23187. 2. The common compounds for modulating arachidonic acid release/pathway, mepacrine and econazole only inhibited L-NG nitroarginine-resistant relaxation in BCA not in PCA. In contrast, proadifen (SKF 525A) diminished relaxation in BCA and PCA. Mepacrine and proadifen inhibited Hoe-234-initiated relaxation in BCA and PCA, while econazole only inhibited Hoe 234-induced relaxation in PCA. Due to the multiple effects of these compounds, caution is necessary in the interpretation of results obtained with these compounds. 3. The inhibitor of Ca(2+)-activated K+ channels, apamin, strongly attenuated A23187-induced L-NG nitroarginine-resistant relaxation in BCA while apamin did not affect L-NG nitroarginine-resistant relaxation in PCA. 4. Pertussis toxin blunted L-NG nitroarginine-resistant relaxation in BCA, while relaxation of PCA was not affected by pertussis toxin. 5. Thi...Continue Reading

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Citations

Jun 9, 1998·European Journal of Pharmacology·B G Hoebel, W F Graier
Aug 5, 1998·Pharmacology & Therapeutics·E Thorin, S M Shreeve
Jun 20, 2001·Trends in Cardiovascular Medicine·M MedhoraD Harder
Jan 5, 2001·British Journal of Pharmacology·H D GibraeilB Mayer
Sep 20, 2005·The British Journal of Ophthalmology·A C BrowningW M Amoaku
Aug 26, 2010·British Journal of Pharmacology·Alexander BondarenkoWolfgang F Graier
Sep 19, 2009·The Journal of International Medical Research·O DagtekinJ H Fischer
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·E ThorinA Bouthillier
Aug 1, 1997·Circulation Research·N L WeintraubA A Spector
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Heiko MetheElazer R Edelman

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