PMID: 6969027Jan 1, 1980Paper

Mechanisms of levamisole-induced granulocytopenia in breast cancer patients

American Journal of Hematology
C L VogelE V Sugarbaker

Abstract

Five of 39 (13%) women treated with adjuvant combination chemotherapy plus levamisole immunotherapy after mastectomy for Stage II or III breast cancer developed levamisole-induced granulocytopenia. This complication occurred in each of the women between six and ten weeks after the completion of six months of combination chemoimmunotherapy when they were taking levamisole alone. Although none of the patients had an HLA B-27 locus and leukoagglutinins could not be demonstrated, complement-dependent, IgM mediated, peripheral destruction of granulocytes was documented using a microgranulocytotoxicity assay. In addition, a factor(s) present in serum from patients developing levamisole-induced granulocytopenia caused suppression of bone marrow granulocyte progenitor cells (CFU-C). The possible relationships between levamisole-induced peripheral granulocyte destruction and bone marrow CFU-C suppression are discussed.

References

Feb 14, 1976·Lancet·M RosenthalW Müller
Jan 31, 1976·Lancet·A F RojasA J Olivari
Jan 1, 1977·Lancet·R Clara, J Germanes
Jan 8, 1977·Lancet·R Vanholder, W Van Hove
May 28, 1977·Lancet·D R ParkinsonG Marquis
Jul 9, 1977·Lancet·K L Schmidt, C Mueller-Eckhardt
Nov 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·T Mahmood, W A Robinson
Aug 1, 1978·Annals of the Rheumatic Diseases·G T WilliamsE C Huskisson
Nov 1, 1978·British Journal of Haematology·H P LohrmannH Heimpel
Jan 16, 1975·The New England Journal of Medicine·B FisherE R Fisher
Jan 1, 1971·The Journal of Experimental Medicine·E RabellinoE R Unanue
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Jan 1, 1969·British Journal of Haematology·S M Worlledge
Mar 1, 1974·Journal of Immunological Methods·C D SeversonJ S Thompson
Jun 1, 1980·The Journal of Clinical Investigation·J S ThompsonJ A Koepke

❮ Previous
Next ❯

Citations

Mar 30, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alexandre Larocque, Robert S Hoffman
Aug 27, 2011·Seminars in Arthritis and Rheumatism·Samuel H PoonAnthony M Reginato
Feb 16, 2010·American Journal of Clinical Pathology·David R CzuchlewskiKathryn Foucar
Jun 2, 2016·American Journal of Clinical Pathology·Yi-Wei Justin LiuMarjan Afrouzian
Dec 7, 2017·Current Opinion in Hematology·Michael J Cascio, Kuang-Yu Jen
Mar 21, 2017·Archives of Toxicology·Tibor Markus BruntBastiaan Venhuis
Nov 1, 1988·Medical Toxicology and Adverse Drug Experience·H Heimpel
Apr 1, 1995·Medical and Pediatric Oncology·E W Winquist, N J Lassam
Dec 11, 2020·Therapeutic Drug Monitoring·Kari M MidthunBarry K Logan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Medical Journal
A F El-Ghobarey, H A Capell
Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine
Jennie WeiGurpreet Dhaliwal
© 2021 Meta ULC. All rights reserved