Mechanisms of lumen narrowing of saphenous vein bypass grafts 12 months after implantation: an intravascular ultrasound study

American Heart Journal
Hideaki KanedaP J Fitzgerald

Abstract

Previous long-term (>1 year) studies have suggested that saphenous vein bypass grafts (SVGs) undergo vascular remodeling similar to native coronary arteries. However, early morphologic stages of SVG remodeling have not been characterized in vivo. Thirty SVGs were studied 12 months after implantation using an intravascular ultrasound automated pullback system. Intravascular ultrasound images were analyzed between 10 and 60 mm from the tip of the guide. Lumen area (LA), intima area (IA), and vessel area (VA, defined as the area within the outer border of a hypoechoic intimal layer) were computed at 3 cross sections: the minimum LA (MLA) site and the proximal and distal reference sites. Area changes (Delta) were calculated as the MLA site minus the average of the reference sites. In this cohort, 70% of the MLA sites had a smaller VA than the average references. On average, MLA sites had significantly smaller VA (9.7 +/- 2.9 vs 10.7 +/- 3.2 mm2, P < .01) and larger IA (2.5 +/- 2.1 vs 1.2 +/- 1.3 mm2, P < .01) than at the reference sites. The relative contribution of DeltaVA (-1.0 +/- 1.4 mm2) and DeltaIA (1.3 +/- 1.3 mm2) to lumen compromise (-2.3 +/- 1.4 mm2) were 43% and 57%, respectively. On the other hand, simple linear regress...Continue Reading

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Citations

Dec 3, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuko WakisakaSoichiro Kitamura
Feb 26, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J MalmstedtJ Swedenborg
Jul 24, 2013·Journal of Vascular Surgery·Peng YuC Keith Ozaki
Aug 28, 2012·Heart, Lung & Circulation·Mihan PourabdollahForoozan Mohammadi
Oct 15, 2011·The Annals of Thoracic Surgery·Soroosh KianiRobert S Poston
Apr 29, 2008·Journal of Vascular Surgery·Christopher D OwensMichael S Conte
Sep 23, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dimitris MitsourasFrank J Rybicki
Jan 22, 2015·Future Cardiology·Andrew MitchellNicholas L Cruden
Apr 11, 2009·Journal of the American College of Cardiology·Young Joon HongNeil J Weissman
Aug 19, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Barbara A DanekEmmanouil Brilakis
Aug 11, 2018·Cell Transplantation·Mehmet H KuralLiqiong Gui

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