Abstract
Previous long-term (>1 year) studies have suggested that saphenous vein bypass grafts (SVGs) undergo vascular remodeling similar to native coronary arteries. However, early morphologic stages of SVG remodeling have not been characterized in vivo. Thirty SVGs were studied 12 months after implantation using an intravascular ultrasound automated pullback system. Intravascular ultrasound images were analyzed between 10 and 60 mm from the tip of the guide. Lumen area (LA), intima area (IA), and vessel area (VA, defined as the area within the outer border of a hypoechoic intimal layer) were computed at 3 cross sections: the minimum LA (MLA) site and the proximal and distal reference sites. Area changes (Delta) were calculated as the MLA site minus the average of the reference sites. In this cohort, 70% of the MLA sites had a smaller VA than the average references. On average, MLA sites had significantly smaller VA (9.7 +/- 2.9 vs 10.7 +/- 3.2 mm2, P < .01) and larger IA (2.5 +/- 2.1 vs 1.2 +/- 1.3 mm2, P < .01) than at the reference sites. The relative contribution of DeltaVA (-1.0 +/- 1.4 mm2) and DeltaIA (1.3 +/- 1.3 mm2) to lumen compromise (-2.3 +/- 1.4 mm2) were 43% and 57%, respectively. On the other hand, simple linear regress...Continue Reading
References
Mar 15, 1992·Journal of the American College of Cardiology·J E WillardP A Grayburn
Aug 15, 1992·The American Journal of Cardiology·S Nase-HueppmeierP Hanrath
Jul 1, 1991·Progress in Cardiovascular Diseases·J L CoxA I Gotlieb
Jun 1, 1990·Journal of the American College of Cardiology·J H IpJ H Chesebro
Nov 15, 1995·The American Journal of Cardiology·F O MendelsohnN J Weissman
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J MannV J Dzau
Feb 15, 1996·Circulation·T NishiokaR J Siegel
Sep 1, 1996·The Annals of Thoracic Surgery·E D Verrier, E M Boyle
Oct 1, 1996·Heart·T HozumiH Okura
Mar 15, 1997·The Journal of Clinical Investigation·M J MannV J Dzau
Oct 23, 1997·Circulation·I J KulloT O'Brien
Apr 1, 1998·Circulation·J G Motwani, E J Topol
Oct 24, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T KobayashiN Komiyama
Nov 14, 1998·Heart·E SalasA J de Belder
Aug 24, 1999·Circulation·Y HuQ Xu
Nov 24, 1999·The American Journal of Cardiology·M K HongM B Leon
Jan 5, 2000·Heart·Y SasakiM Ueda
Jan 25, 2000·Circulation·S J GeorgeA H Baker
Feb 7, 2001·Journal of Vascular Surgery·A K HannaM A Golden
Nov 18, 2000·British Journal of Pharmacology·N SogoI L Megson
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·A EhsanV J Dzau
Apr 13, 2001·Journal of the American College of Cardiology·G S MintzP G Yock
Jun 15, 2001·Gene Therapy·S J GeorgeA H Baker
Aug 14, 2001·Journal of the American College of Cardiology·P SchoenhagenE M Tuzcu
Citations
Dec 3, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuko WakisakaSoichiro Kitamura
Feb 26, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J MalmstedtJ Swedenborg
Jul 24, 2013·Journal of Vascular Surgery·Peng YuC Keith Ozaki
Aug 28, 2012·Heart, Lung & Circulation·Mihan PourabdollahForoozan Mohammadi
Oct 15, 2011·The Annals of Thoracic Surgery·Soroosh KianiRobert S Poston
Sep 12, 2009·The Canadian Journal of Cardiology·Olivier F BertrandUNKNOWN VICTORY trial investigators
Aug 3, 2010·Atherosclerosis·Frances O WoodEmmanouil S Brilakis
Apr 29, 2008·Journal of Vascular Surgery·Christopher D OwensMichael S Conte
Sep 23, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dimitris MitsourasFrank J Rybicki
Jan 22, 2015·Future Cardiology·Andrew MitchellNicholas L Cruden
May 4, 2015·Journal of Vascular Surgery·Richard D KenagyAlexander W Clowes
Oct 20, 2009·Journal of Vascular Surgery·Christopher D Owens
Apr 11, 2009·Journal of the American College of Cardiology·Young Joon HongNeil J Weissman
Aug 19, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Barbara A DanekEmmanouil Brilakis
Jan 31, 2018·Acta Radiologica·Dimitrios MitsourasFrank J Rybicki
Aug 11, 2018·Cell Transplantation·Mehmet H KuralLiqiong Gui