Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design

Cell Host & Microbe
Joel D Ernst

Abstract

Tuberculosis (TB) is a large global health problem, in part because of the long period of coevolution of the pathogen, Mycobacterium tuberculosis, and its human host. A major factor that sustains the global epidemic of TB is the lack of a sufficiently effective vaccine. While basic mechanisms of immunity that protect against TB have been identified, attempts to improve immunity to TB by vaccination have been disappointing. This Review discusses the mechanisms used by M. tuberculosis to evade innate and adaptive immunity and that likely limit the efficacy of vaccines developed to date. Despite multiple mechanisms of immune evasion, recent trials have indicated that effective TB vaccines remain an attainable goal. This Review discusses how knowledge from other systems can inform improvements on current vaccine approaches.

Citations

Dec 2, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhidong HuXiao-Yong Fan
Nov 2, 2019·Clinical Microbiology Reviews·Suraj B SableThomas J Scriba
Mar 3, 2020·Frontiers in Immunology·José Alberto Choreño-ParraRogelio Hernández-Pando
Apr 14, 2019·Nature Reviews. Microbiology·Nathalie Q BalabanAnnelies Zinkernagel
Sep 4, 2019·The Journal of Clinical Investigation·Shabaana A KhaderUNKNOWN Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18
Sep 30, 2020·Cells·Alessandro SinigagliaLuisa Barzon
May 6, 2020·JCI Insight·Jeffrey M CollinsThomas R Ziegler
May 23, 2019·Nature Reviews. Immunology·Peter Andersen, Thomas J Scriba
Aug 30, 2020·International Journal of Molecular Sciences·Freya R Shepherd, James E McLaren
Feb 3, 2021·The Journal of Clinical Investigation·W Henry BoomJacqueline M Achkar
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dilara Kiran, Randall J Basaraba
May 25, 2021·Biotechnology Letters·Gerardo García-GonzálezJosé Prisco Palma-Nicolás
May 25, 2021·Frontiers in Cellular and Infection Microbiology·Igor Santiago-CarvalhoMaria Regina D'Império Lima
Jul 27, 2021·Frontiers in Cellular and Infection Microbiology·Feifei WangHongbo Shen
Sep 3, 2020·Cellular Immunology·Aayushi SinghKrishnamurthy Natarajan

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