PMID: 2120138Oct 15, 1990Paper

Mechanisms of macrophage-mediated tumor cell killing: a comparative analysis of the roles of reactive nitrogen intermediates and tumor necrosis factor

International Journal of Cancer. Journal International Du Cancer
R KellerP H Van der Meide

Abstract

The roles of tumor necrosis factor (TNF alpha) and reactive nitrogen intermediates (RNI) as effectors of macrophage-mediated tumor cell killing were investigated in a variety of tumor cell lines. Three TNF alpha-sensitive tumor targets were also susceptible to resting bone-marrow-derived mononuclear phagocytes (BMMP). This macrophage lytic activity was markedly diminished or even abolished by anti-TNF alpha, indicating that TNF alpha is the major effector of macrophage-mediated killing of these targets. The other 21 tumor cell lines examined were resistant to TNF alpha but, in their large majority, were more or less susceptible to killing by interferon gamma (IFN gamma)- and Corynebacterium parvum (CP)-activated BMMP. Among the various analogues of L-arginine used to assess the role of L-arginine-derived RNI as mediators of macrophage tumoricidal activity, NG-monomethyl-L-arginine (NMMA) was most efficient in suppressing RNI secretion by activated macrophages. In some macrophage tumor-cell combinations, NMMA inhibited both the generation of RNI and the expression of tumoricidal activity in a dose-dependent manner, suggesting a central role for RNI as effectors. In other combinations, NMMA in concentrations that abolished secret...Continue Reading

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Citations

Feb 6, 1996·Cancer Letters·W K LiuC T Che
Mar 15, 2005·Journal of Ethnopharmacology·Ming-Jiuan WuTzi-Wei Lian
Feb 21, 2006·Mediators of Inflammation·Anselmo Hernández CruzVera L Petricevich
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Sep 18, 2012·Glycoconjugate Journal·Olga TarasenkoPierre Alusta
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Aug 7, 2007·Toxicon : Official Journal of the International Society on Toxinology·Vera L PetricevichLourival D Possani
Nov 1, 2005·Life Sciences·M SakaiJ Palermo-Neto
Sep 4, 2013·Toxicon : Official Journal of the International Society on Toxinology·E S CostaS C Sampaio
Aug 13, 2011·Peptides·Patricia Dias FernandesPierre Sirois
Oct 30, 2012·Journal of Ethnopharmacology·A L Alvarez Perez GilV L Petricevich
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Lluvia Arteaga FigueroaVera L Petricevich
Mar 8, 2003·The Journal of Laboratory and Clinical Medicine·George G ChenWai S Poon
Mar 20, 2008·Neuroimmunomodulation·Glaucie Jussilane AlvesJoão Palermo-Neto
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Jan 17, 2002·Bioscience, Biotechnology, and Biochemistry·K I KimH C Yang
Mar 1, 1994·British Journal of Haematology·V ChanT K Chan

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