Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity.

Frontiers in Endocrinology
Lucie OrliaguetFawaz Alzaid

Abstract

Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst metabolic inflammation is characterized as systemic, a common starting point is the tissue-resident macrophage, who's successful physiological or aberrant pathological adaptation to its microenvironment determines disease course and severity. This review will highlight the key mechanisms in macrophage polarization, inflammatory and non-inflammatory signaling that dictates the development and progression of insulin resistance and T2D. We first describe the known homeostatic functions of tissue macrophages in insulin secreting and major insulin sensitive tissues. Importantly we highlight the known mechanisms of aberrant macrophage activation in these tissues and the ways in which this leads to impairment of insulin sensitivity/secretion and the development of T2D. We next describe the cellular mechanisms that are known to dictate macrophage polarization. We review recent progress in macrophage bio-energetics, an emerging field of research that places cellular metabolism at the center of immune-effector function. Importantly, following the advent of the met...Continue Reading

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Veronica D DahikWilfried Le Goff
Aug 14, 2020·International Journal of Molecular Sciences·Lucie OrliaguetFawaz Alzaid
Feb 4, 2021·International Journal of Molecular Sciences·Hiroshi Kitamura, Mayuko Hashimoto
Feb 19, 2021·Metabolic Syndrome and Related Disorders·Iveta NedevaZdravko Kamenov
Jan 14, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guanghong JiaJames R Sowers
Mar 7, 2021·International Journal of Molecular Sciences·Paula O CooperBrett A Shook
Mar 30, 2021·Diabetes & Metabolism Journal·Anni M Y ZhangJames D Johnson
May 29, 2021·Molecular and Cellular Endocrinology·Victoria Fernández-GarcíaLisardo Boscá
Aug 20, 2021·Scientific Reports·Marco Youssef William ZakiHelen Louise Reeves
Aug 9, 2021·Biochemical Pharmacology·Marjorie Reyes-FariasDavid Sánchez-Infantes
Sep 25, 2021·Antioxidants & Redox Signaling·Lincon Felipe Lima-SilvaPedro Moraes Vieira

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Methods Mentioned

BETA
single-cell sequencing
transgenic
histone acetylation
nuclear translocation
acetylation
single cell sequencing

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