Mechanisms of Memory T Cell Activation and Effective Immunity

Advances in Experimental Medicine and Biology
Grégoire Lauvau, Saidi M'Homa Soudja

Abstract

Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection.

Citations

Jul 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre E NowillPedro O de Campos-Lima
Jan 30, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna Cline-SmithRajeev Aurora
Aug 1, 2020·Frontiers in Immunology·Elke M MuntjewerffGeert van den Bogaart
Mar 22, 2020·International Journal of Molecular Sciences·J Matthew NicklasPeter K Henke
Feb 2, 2020·Cellular & Molecular Immunology·Sadiye Amcaoglu RiederRoland Kolbeck
Mar 19, 2021·Journal of Cellular and Molecular Medicine·Monica NeaguAristidis Tsatsakis

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