Mechanisms of Metastasis and Cell Mobility - The Role of Metabolism

Geburtshilfe und Frauenheilkunde
Carsten GründkerGünter Emons

Abstract

Tumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the "metastatic cascade" or "metastatic cycle" is a complex and multi-stage event. While it is generally recognised that epithelial-mesenchymal transformation (EMT) plays a crucial role in cancer progression and metastasis, the metabolic events in this process have received little attention to date. We would therefore like to provide a brief overview here of the influence of the metabolism on the progression and metastasis of tumours.

Citations

Dec 19, 2019·Frontiers in Immunology·Giuseppe ErcolanoCamilla Jandus

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