PMID: 11915930Mar 28, 2002Paper

Mechanisms of muscle insulin resistance in obese individuals

International Journal of Sport Nutrition and Exercise Metabolism
G L Dohm

Abstract

We previously reported that insulin resistance in skeletal muscle of obese individuals was associated with decreases in insulin signal transduction and tyrosine kinase activity of the insulin receptor. Herein is reviewed the recently published data supporting the hypothesis that protein kinase C (PKC) phosphorylates the insulin receptor on serine/threonine residues to decrease tyrosine kinase activity and cause insulin resistance. Treatment of insulin receptors from obese subjects with alkaline phosphatase restored tyrosine kinase activity, suggesting that the reduced activity was a result of hyperphosphorylation of the receptor. Incubating human muscle fiber strips with PKC inhibitors restored insulin action in muscle of obese patients, while activating PKC with a phorbol ester caused insulin resistance in muscle from lean control patients. The beta isoform of PKC was elevated in muscle of obese, insulin-resistant patients. These data are consistent with the hypothesis that elevated PKC activity may cause insulin resistance by phosphorylating the insulin receptor to decrease tyrosine kinase activity.

Citations

Jun 12, 2008·Journal of Strength and Conditioning Research·Paul E LuebbersDale S Bond
May 28, 2004·Metabolism: Clinical and Experimental·ZengKui Guo, Lianzhen Zhou

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