Mechanisms of NAFLD development and therapeutic strategies

Nature Medicine
Scott L FriedmanArun J Sanyal

Abstract

There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and liver cancer. Here we review the pathogenic and clinical features of NAFLD, its major comorbidities, clinical progression and risk of complications and in vitro and animal models of NAFLD enabling refinement of therapeutic targets that can accelerate drug development. We also discuss evolving principles of clinical trial design to evaluate drug efficacy and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression.

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Methods Mentioned

BETA
biopsy
imaging
biopsies
bioprinting
transgenic
targeted mutations
pharmacotherapies
pharmacotherapy

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NCT03028740
NCT02704403
NCT02548351
NCT03439254
NCT03053050
NCT03053063
NCT02279524
NCT02413372
NCT03421431
NCT02686762

Software Mentioned

RESOLVE

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