Mechanisms of nanoparticle radiosensitization.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Ivan M Kempson

Abstract

Metal-based nanoparticles applied to potentiating the effects of radiotherapy have drawn significant attention from the research community and are now available clinically. By improving our mechanistic understanding, nanoparticles are likely to evolve to provide very significant improvements in radiotherapy outcomes with only incremental increase in cost. This review critically assesses the inconsistent observations surrounding physical, physicochemical, chemical and biological mechanisms of radiosensitization. In doing so, a number of needs are identified for continuing research and are highlighted. The large degree of variability from one nanoparticle to another emphasizes that it is a mistake to generalize nanoparticle radiosensitizer mechanisms. Nanoparticle formulations should be considered in an analogous way as pharmacological agents and as a broad class of therapeutic agents, needing to be considered with a high degree of individuality with respect to their interactions and ultimate impact on radiobiological response. In the same way that no universal anti-cancer drug exists, it is unlikely that a single nanoparticle formulation will lead to the best therapeutic outcomes for all cancers. The high degree of complexity an...Continue Reading

References

Nov 1, 2000·International Journal of Radiation Biology·D M HeroldJ D Chapman
Feb 26, 2003·Radiation Research·Shu-Jun ChiuLih-Yuan Lin
May 20, 2004·Journal of the American Chemical Society·Joanna BerdysJack Simons
Aug 25, 2004·Physical Review Letters·Frédéric MartinLéon Sanche
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Nov 25, 2005·Journal of the American Chemical Society·Yi ZhengJ Richard Wagner
Feb 4, 2006·Science·Andre NelNing Li
Jun 19, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Hirak K PatraAnjan Kr Dasgupta
Apr 9, 2008·Biomaterials·Eric G HeckertWilliam T Self
Dec 17, 2008·Journal of the American Chemical Society·Hong Ying JiaYuan Chao Xu
Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
Jan 22, 2010·Physics in Medicine and Biology·Chi-Jen LiuG Margaritondo
Apr 7, 2010·Chemical Communications : Chem Comm·Talib PirmohamedWilliam T Self
Apr 30, 2010·Archives of Toxicology·Rasmus FoldbjergHerman Autrup
Jun 4, 2010·Radiation Research·Devika B ChithraniDavid A Jaffray
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Suneil JainDavid G Hirst
Apr 12, 2011·Journal of Nanobiotechnology·Hsiang-Hsin ChenGiorgio Margaritondo
May 4, 2011·Analytical and Bioanalytical Chemistry·Xiaoqing CaiG Margaritondo
Nov 8, 2011·Nature Nanotechnology·Jong Ah KimKenneth A Dawson
Jan 21, 2012·Journal of the American Chemical Society·Neal N ChengTing Guo
Jun 16, 2012·International Journal of Nanomedicine·Jonathan A CoulterKevin M Prise
Jul 7, 2012·Nanoscale·Karl T ButterworthKevin M Prise
Oct 4, 2012·Future Oncology·Laurence MaggiorellaLaurent Levy
Nov 28, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Melissa S WasonCheryl H Baker
Mar 29, 2013·Biochemical and Biophysical Research Communications·Stefanie KleinCarola Kryschi
Jul 24, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·J A CoulterF J Currell
Oct 12, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Cuihong WangLikuan Hu
May 28, 2014·Small·Cécile Sicard-RoselliFrederick Currell
Jun 19, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Matthew LuchetteRoss Berbeco
Jul 2, 2014·Radiation Oncology·Julie MarillAgnes Pottier
Jul 6, 2014·The British Journal of Radiology·L SanceyO Tillement
Sep 23, 2014·Cancer Nanotechnology·Laura E TaggartKarl T Butterworth
Sep 24, 2014·Radiology·Fabian KiesslingTwan Lammers

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Citations

Jul 3, 2021·International Journal of Molecular Sciences·Roxana Cristina PopescuMarlon R Veldwijk

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