Mechanisms of opsonized HIV entry in normal B lymphocytes

FEBS Letters
C LegendreD Dormont

Abstract

Using our in vitro model of normal B cell infection that functions with low doses of HIV but requires virus opsonization by seropositive patient serum, and complement, we analyzed what receptors allowed virus entry. Here, we show that HIV infection of B cells occurs through 2 major receptors: the CD4 antigen and the CR1/CR2 complex. These 2 pathways work independently since a complete inhibition of virus entry requires both CD4 and CD21/CD35 blockade on CD4dim tonsillar B cells whereas only the latter is critical on CD4-negative B cells.

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Citations

Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·R E DavisW D Parker
Jan 7, 1998·Immunological Reviews·C SpethM P Dierich
Jan 1, 1997·Annual Review of Immunology·H StoiberM P Dierich
Jul 27, 2002·Cellular Immunology·Yongmao YuMichael Schlesinger
Nov 4, 2000·Expert Opinion on Investigational Drugs·C PintérA Clivio
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P K Datta, J Rappaport
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zsuzsa BajtayManfred P Dierich
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eliska HorakovaJürg A Schifferli

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