Abstract
Recent evidence indicates that MHC peptides play an important role in T-cell recognition of alloantigen. We studied the tolerogenicity of orally administered synthetic MHC allopeptides in the rat model. Initially, we demonstrated that oral administration of synthetic class II MHC allopeptides significantly inhibited the DTH response to the peptides as well as to donor-derived cells. The tolerogenic effect was antigen specific and was induced by immunogenic, but not by nonimmunogenic, allopeptides. Immunohistological studies of DTH skin lesions showed that oral tolerance is associated with a state of "immune deviation" to a predominance of Th2 cell function in the lesions. We recently extended the above observations and examined the tolerogenic effect of orally administered synthetic MHC allopeptides on MLR and CTL generation. We found that oral administration of the class II allopeptides effected significant reduction of MLR proliferation and CTL generation, which was antigen specific. In addition, similar to the DTH results when we compared the tolerogenicity of the immunogenic versus the nonimmunogenic peptides, MLR and CTL suppression was significantly higher with the immunogenic peptides. The gut immune system play an impor...Continue Reading
References
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M H SayeghC B Carpenter
Jun 1, 1992·The Journal of Experimental Medicine·J FangmannJ W Fabre
Jun 1, 1992·European Journal of Immunology·J FangmannJ W Fabre
Oct 1, 1991·The Journal of Experimental Medicine·A MillerH L Weiner
Jan 1, 1992·The Journal of Experimental Medicine·G BenichouE E Sercarz
Jan 1, 1992·Transplantation·M H SayeghH L Weiner
Feb 22, 1990·The New England Journal of Medicine·A M KrenskyP Parham
Aug 26, 1994·Science·Y ChenH L Weiner
Jun 1, 1993·The Journal of Experimental Medicine·Z LiuN Suciu-Foca
Apr 15, 1995·Transplantation·A M BenhamJ W Fabre
Oct 1, 1994·Current Opinion in Immunology·A M Krensky, C Clayberger
Nov 1, 1994·Gastroenterology·J M BrandeisC B Carpenter
Jan 1, 1994·Annual Review of Immunology·H L WeinerD A Hafler
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Friedman, H L Weiner
Jan 1, 1993·Transplantation·M Y BraunJ R Batchelor
Mar 1, 1994·The Journal of Experimental Medicine·R S LeeH Auchincloss
Jan 1, 1994·Immunology Today·D A Shoskes, K J Wood
May 15, 1994·Transplantation·M H SayeghC B Carpenter
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H AuchinclossL H Glimcher
May 1, 1993·Transplantation·W W HancockC B Carpenter
Jan 1, 1996·International Reviews of Immunology·M H Sayegh, C B Carpenter
Citations
Mar 15, 2002·Current Allergy and Asthma Reports·O Alpan
Mar 9, 2000·Journal of Reproductive Immunology·C A KoelmanF H Claas
Mar 31, 1999·Immunology Today·D S Gould, H Auchincloss
Oct 9, 2002·Human Immunology·Ben M IlligensGilles Benichou
Nov 22, 1997·Current Opinion in Immunology·C C Magee, M H Sayegh
Oct 14, 2003·International Immunopharmacology·Imed Ben NasserDaniel Tome
May 25, 2004·Nature Immunology·Oral AlpanPolly Matzinger
Dec 31, 1997·The Journal of Clinical Investigation·R KalluriE G Neilson
Dec 12, 2012·Clinical & Developmental Immunology·Christopher Glenn WallaceFu-Chan Wei
Jul 1, 2014·Human Immunology·Adam S A Gracon, David S Wilkes
Feb 27, 2007·Medical Hypotheses·M R Namazi
May 12, 2007·Transplant Immunology·Byram W BridleBonnie A Mallard
Jul 24, 2008·Clinical Transplantation·Karl L WomerCharles B Carpenter
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L Mayer
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L A DettinoM N Sato
Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Apr 29, 2020·Pathology International·Masahiro Kusunoki-IiShinsuke Kato
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gary W HallerDavid H Sachs