Mechanisms of pain in angina pectoris--a critical review of the adenosine hypothesis

Cardiovascular Drugs and Therapy
C Sylvén


Clinical characteristics: Angina pectoris represents a visceral pain caused by reversible myocardial ischemia. The majority of ischemic attacks are symptomless. When pain is manifested, it appears late during the ischemic event. The pain is complex in its quality and bears little relation to the region of myocardial ischemia. Pain shows a sensitive dependence on initial conditions suggesting a mechanism with deterministic chaotic dynamics for the association between myocardial ischemia and pain. Neurophysiological substrate: Ganglia are present within the heart, particularly in epicardial fat. The blood supply of intrinsic cardiac ganglia arises primarily from branches of the proximal coronary arteries. Both afferent and efferent neurons within the intrinsic cardiac nervous system exist, while the majority of neurons in that location may be local circuit neurons. Integration takes place not only in the intrinsic cardiac nervous system, but also in mediastinal, middle cervical, and stellate ganglia. Cardiac afferent receptors are also connected to cell bodies in dorsal root and nodose ganglia, as well as intrathoracic ganglia. Myocardial regions have no spatial representation in these ganglia. Adenosine, among a number of substa...Continue Reading


Jan 1, 1979·Reviews of Physiology, Biochemistry and Pharmacology·P Thorén
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q Y ZhouO Civelli
Sep 1, 1992·The Annals of Thoracic Surgery·D A Murphy, J A Armour
Jul 1, 1992·Progress in Cardiovascular Diseases·A MaseriG J Davies
Sep 16, 1992·Biochemical and Biophysical Research Communications·F LibertK D Mendla
Feb 1, 1992·Cardiovascular Research·W Klement, J O Arndt
Jul 1, 1991·British Medical Bulletin·A H Dickenson
Jul 1, 1990·Journal of Cardiovascular Pharmacology·B LagerqvistA Waldenström
Jan 13, 1990·Lancet·P Collins, K M Fox
Nov 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·A RubinoF Ledda
Feb 1, 1991·Journal of the American College of Cardiology·A MaseriT Crake
May 1, 1991·Circulation·I BiaggioniD Robertson
Dec 31, 1990·Biochemical and Biophysical Research Communications·C MaenhautS Schiffmann
Jul 1, 1990·Physiological Reviews·R A Olsson, J D Pearson
May 1, 1990·Respiration Physiology·M RunoldN R Prabhakar
Nov 1, 1990·Journal of the American College of Cardiology·R O CannonS E Epstein
Oct 1, 1990·Journal of Applied Physiology·K SahlinS F Lewis
Jan 1, 1990·Circulation·F CreaA Maseri
May 1, 1990·American Heart Journal·D B Ramsdale, C M Bellamy
Jan 21, 1986·European Journal of Pharmacology·L E GustafssonB Cederqvist
Nov 1, 1989·European Heart Journal·M MarzilliA L'Abbate
May 1, 1989·Trends in Pharmacological Sciences·J SawynokT D White
Sep 1, 1989·European Heart Journal·S Lévy
Sep 1, 1989·Cardiovascular Research·B JonzonL Kaijser
Apr 1, 1989·Journal of the Autonomic Nervous System·D A Hopkins, J A Armour
Aug 1, 1989·The Journal of Clinical Investigation·D A CoxP Ganz


Jun 18, 1999·Herz·A WilkeB Maisch
May 1, 1994·Journal of Internal Medicine·B ErikssonC Sylvén
Jan 1, 1997·Acta Anaesthesiologica Scandinavica. Supplementum·A Sollevi
Mar 30, 2010·Acta Physiologica·Geoffrey BurnstockA Verkhratsky
Apr 9, 2008·Journal of Pain and Symptom Management·Michael H McGillionAnthony Graham
Jul 2, 2009·Autonomic & Autacoid Pharmacology·Geoffrey Burnstock
Apr 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S W Rabkin
Dec 21, 2014·Purinergic Signalling·Geoffrey Burnstock, Amir Pelleg
Apr 1, 1999·Annual Review of Physiology·R D Foreman
Dec 1, 1996·Journal of the American College of Cardiology·T HashinoT Imaizumi
Jun 7, 2018·Cardiology·Cristina BallaRoberto Ferrari
Dec 13, 1997·Circulation·F Crea, A Gaspardone
Nov 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jiang XuAmir Pelleg
Feb 23, 2007·The American Journal of Gastroenterology·Satish S C RaoBridget Zimmerman
Jul 21, 2005·Journal of Anesthesia·Masakazu HayashidaAtsuo Fukunaga
Apr 27, 2019·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Elad MaorOffer Amir
May 30, 2019·Pain Management·Carlos J RoldanBilly Huh
Mar 11, 1999·Anesthesia and Analgesia·K F SjölundA Sollevi
Jun 12, 2013·Nature Reviews. Cardiology·Tim P van de HoefJan J Piek
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J ChandlerR D Foreman
May 11, 2018·The Journal of Endocrinology·Patrik ŠimjákMartin Haluzík
Nov 25, 2015·Physiological Research·Z MatlochM Haluzík

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.