Mechanisms of patulin toxicity under conditions that inhibit yeast growth

Journal of Agricultural and Food Chemistry
Yumiko IwahashiHitoshi Iwahashi

Abstract

Patulin, 4-hydroxy-4H-furo[3,2c]pyran-2(6H)-one, is one of the best characterized and most widely disseminated mycotoxins found in agricultural products. Nonetheless, the mechanisms by which patulin causes toxicity are not well understood. Thus, the cytotoxicity of patulin was characterized by analysis of the yeast transcriptome upon challenge with patulin. Interestingly, patulin-induced yeast gene expression profiles were found to be similar to gene expression patterns obtained after treatment with the antifungal agricultural chemicals thiuram, maneb, and zineb. Moreover, patulin treatment was found to activate protein degradation, especially proteasome activities, sulfur amino acid metabolism, and the defense system for oxidative stress. Damage to DNA by alkylation was also suggested, and this seemed to be repaired by recombinational and excision repair mechanisms. Furthermore, the results provide potential biomarker genes for the detection of patulin in agricultural products. The results suggest the possibility of applying the yeast transcriptome system for the evaluation of chemicals, especially for natural chemicals that are difficult to get by organic synthesis.

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Citations

Jul 10, 2010·Applied Microbiology and Biotechnology·Lu YuXuming Deng
Jun 6, 2009·Applied Biochemistry and Biotechnology·Daisuke YasokawaHitoshi Iwahashi
Mar 31, 2009·International Journal of Molecular Sciences·Yumiko IwahashiHitoshi Iwahashi
Jan 12, 2016·Toxicon : Official Journal of the International Society on Toxinology·Gábor PappMiklós Pesti
Jul 14, 2010·Journal of Bioscience and Bioengineering·Daisuke Yasokawa, Hitoshi Iwahashi
May 1, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eszter HorváthMiklós Pesti
Jun 6, 2008·Environmental Toxicology·Daisuke YasokawaHitoshi Iwahashi
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Oct 21, 2021·Bioscience, Biotechnology, and Biochemistry·Zuoqian LiHitoshi Iwahashi

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