PMID: 3320549Jan 1, 1987Paper

Mechanisms of physiological and pharmacological sex hormone action on the mammalian liver

Journal of Steroid Biochemistry
E R Lax

Abstract

Androgen and oestrogen receptors have been demonstrated in mammalian liver, but since it is generally accepted that they are probably non-functional at endogenous steroid concentrations, it is not apparent how they mediate physiological influences on this organ. Nor is it certain to what extent pharmacological actions of sex hormones reflect overstimulation of physiological routes or whether alternative mechanisms become available once threshold values have been reached. In this presentation an attempt has been made to answer some of these questions using data obtained from a study of the regulation of the activities of microsomal 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSDH) and 5 alpha-reductase in rat liver. Androgens exert their primary physiological and pharmacological influences at the level of the hypothalamus. Oestrogens can elicit three different types of effect-physiological, antiandrogenic and pharmacological--of which the first two involve primary effects on the pituitary. Hepatic oestrogen receptors only become activated when oestrogen concentrations reach pharmacological levels. Progestins probably have no physiological influence on the livers of non-pregnant rats. Their pharmacological actions may either be...Continue Reading

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Citations

Dec 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E M LaurenzanaK B Delclos
Jul 20, 2002·The Journal of Steroid Biochemistry and Molecular Biology·C H Lee, A M Edwards
Sep 1, 1989·Journal of Steroid Biochemistry·M TetsuoJ Sjövall
Sep 28, 1990·Biochemical and Biophysical Research Communications·M Mesarić, K Decker
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerF Hardt
Jan 15, 1992·Physical Review. a·C R DoeringM L Glasser
Aug 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J Durian

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