PMID: 22338573Feb 18, 2012Paper

Mechanisms of platelet activation in acute coronary syndromes

Current Vascular Pharmacology
Dimitrios A StakosKonstantinos Stellos

Abstract

Platelets are known to play a fundamental role in acute coronary syndromes. After atherosclerotic plaque rupture, platelets can form pathogenic, occlusive thrombi leading to acute ischemic events. Today there are promising results from recently developed antiplatelet agents. However, morbidity and mortality from acute coronary syndromes remain significant despite the administration of combination therapies (aspirin, thienopyridines). Sharing similar mechanisms, platelets may also form a thin monolayer in areas of damaged endothelium contributing to primary hemostasis. For this reason, administration of antiplatelet drugs is often associated with increased bleeding risk. As a result, currently available antiplatelet therapy cannot be characterized as optimal. The precise mechanisms of platelet activation in acute coronary syndromes are still under investigation. The study of basic mechanisms of platelet adhesion, activation and aggregation after atherosclerotic plaque rupture may help to define new targets for their inhibition. In the future, newer antiplatelet agents may offer more comprehensive platelet inhibition without interfering with primary hemostasis, thus offering greater protection with lower hemorrhagic risk.

Citations

Feb 27, 2016·European Heart Journal·David M LeistnerAndreas M Zeiher
Jul 11, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jeffrey S Berger
Apr 15, 2020·Cardiovascular Therapeutics·Giuseppe PattiLeonardo Bolognese
Jan 4, 2017·Disease Markers·Michal BijakMarzenna Zielinska
Feb 6, 2019·Cells·Joanna Saluk-BijakMichal Bijak
Oct 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartosz SkalskiJerzy Żuchowski
Jun 25, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rafal SzelenbergerMarzenna Zielinska
May 4, 2021·Frontiers in Physiology·Pamela CzajkaMarek Postula
Aug 27, 2017·International Journal of Biological Macromolecules·Michal BijakJoanna Saluk-Bijak

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