PMID: 11604561Oct 18, 2001Paper

Mechanisms of platelet aggregation

Current Opinion in Hematology
B SavageZaverio M Ruggeri

Abstract

Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.

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