Apr 12, 2014

Mechanisms of post-transcriptional gene regulation in bacterial biofilms

Frontiers in Cellular and Infection Microbiology
Luary C Martínez, Viveka Vadyvaloo


Biofilms are characterized by a dense multicellular community of microorganisms that can be formed by the attachment of bacteria to an inert surface and to each other. The development of biofilm involves the initial attachment of planktonic bacteria to a surface, followed by replication, cell-to-cell adhesion to form microcolonies, maturation, and detachment. Mature biofilms are embedded in a self-produced extracellular polymeric matrix composed primarily of bacterial-derived exopolysaccharides, specialized proteins, adhesins, and occasionally DNA. Because the synthesis and assembly of biofilm matrix components is an exceptionally complex process, the transition between its different phases requires the coordinate expression and simultaneous regulation of many genes by complex genetic networks involving all levels of gene regulation. The finely controlled intracellular level of the chemical second messenger molecule, cyclic-di-GMP is central to the post-transcriptional mechanisms governing the switch between the motile planktonic lifestyle and the sessile biofilm forming state in many bacteria. Several other post-transcriptional regulatory mechanisms are known to dictate biofilm development and assembly and these include RNA-bi...Continue Reading

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  • Citations9
  • References181
  • Citations9


Mentioned in this Paper

Gene Expression Regulation, Bacterial
Adhesins, Bacterial
Bacterial Proteins
Post-Transcriptional Regulation
Pathogenic Organism

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