Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Nature Reviews. Genetics
Witold FilipowiczNahum Sonenberg

Abstract

MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In mammals, microRNAs are predicted to control the activity of approximately 30% of all protein-coding genes, and have been shown to participate in the regulation of almost every cellular process investigated so far. By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation. This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function.

References

Aug 14, 1998·Molecular Cell·S E WellsA B Sachs
Feb 26, 2003·Genes & Development·John G DoenchPhillip A Sharp
Dec 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·John KimGary Ruvkun
Jan 9, 2004·The Journal of Biological Chemistry·Jin-Yu Lu, Robert J Schneider
Jan 30, 2004·Nature Structural & Molecular Biology·Roy Parker, Haiwei Song
Feb 19, 2004·RNA·Peter T NelsonZissimos Mourelatos
Feb 26, 2004·Nucleic Acids Research·Nicola Minshall, Nancy Standart
Mar 12, 2004·Genes & Development·John G Doench, Phillip A Sharp
Jun 11, 2004·Annual Review of Biochemistry·Lee D Kapp, Jon R Lorsch
Jul 9, 2004·Developmental Cell·Arie Koen BraatPaul M Macdonald
Jul 21, 2004·Molecular Cell·Gunter MeisterThomas Tuschl
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Nov 2, 2004·Nature Cell Biology·Peng JinStephen T Warren
Dec 9, 2004·Nucleic Acids Research·Wigard P KloostermanRonald H A Plasterk
Jan 18, 2005·Nature Reviews. Molecular Cell Biology·Erik J Sontheimer
Feb 4, 2005·Nature·Joel D Richter, Nahum Sonenberg
Feb 22, 2005·PLoS Biology·Julius BrenneckeStephen M Cohen
Apr 21, 2005·RNA·Maria Alexandra AndreiReinhard Lührmann
Jun 1, 2005·Current Opinion in Structural Biology·Witold FilipowiczRamesh S Pillai
Jun 7, 2005·Nature Cell Biology·Jidong LiuRoy Parker
Jun 22, 2005·The Journal of Cell Biology·Nancy KedershaPaul Anderson
Aug 6, 2005·Science·Ramesh S PillaiWitold Filipowicz
Aug 27, 2005·Cell·Shveta BaggaAmy E Pasquinelli
Sep 15, 2005·The Journal of Cell Biology·Maria A FerraiuoloNahum Sonenberg

❮ Previous
Next ❯

Citations

Jun 27, 2008·Cellular and Molecular Life Sciences : CMLS·M N Hinman, H Lou
May 25, 2011·Cellular and Molecular Life Sciences : CMLS·Julia Starega-RoslanWlodzimierz J Krzyzosiak
Feb 7, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin Busch, Alma Zernecke
Jun 16, 2011·European Biophysics Journal : EBJ·Arne WernerUlrich Hahn
Nov 26, 2008·World Journal of Surgery·Min LiChangyi Chen
Nov 15, 2013·Der Pathologe·D Baumhoer
Oct 8, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paulo P Amaral, John S Mattick
Sep 26, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jo Peters, Joan E Robson
Sep 4, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Enpeng ZhaoAlan D Attie
Dec 17, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Li LiHongfei Wang
Mar 20, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Martin MiklMichael A Kiebler
Jul 3, 2010·Molecular Genetics and Genomics : MGG·Keita MiyoshiHaruhiko Siomi
Jan 22, 2013·Molecular Genetics and Genomics : MGG·S AroraV Rani
Apr 25, 2012·Cell and Tissue Research·Sajjad Sisakhtnezhad, Maryam M Matin
May 25, 2012·Cell and Tissue Research·Mahboob Ul Hussain
Jan 29, 2010·Functional & Integrative Genomics·Maheshi DassanayakeJohn M Cheeseman
Nov 29, 2011·Apoptosis : an International Journal on Programmed Cell Death·Ji FangLi Lin
Jun 4, 2011·Breast Cancer Research and Treatment·Muhua YangQun Zhou
Oct 13, 2010·Cancer Metastasis Reviews·Ming ShiNing Guo
Oct 19, 2011·Cancer Metastasis Reviews·Ashleigh E MooreDan A Dixon
Apr 16, 2010·Journal of Clinical Immunology·Lukas T Jeker, Jeffrey A Bluestone
May 10, 2011·Molecular and Cellular Biochemistry·Yanjie GuoJianing Zhang
Oct 1, 2013·Molecular Biology Reports·Katarzyna HamaraJanusz Szemraj
Jan 25, 2012·Journal of Neuro-oncology·Fonnet E BleekerSieger Leenstra
Jan 12, 2013·Journal of Neuro-oncology·Fadila GuessousRoger Abounader
Aug 6, 2011·Pharmaceutical Research·Ailbhe M McDermottMichael J Kerin
Mar 20, 2010·Plant Molecular Biology·Fabián E VaistijLouise Jones
Aug 30, 2011·Plant Molecular Biology·Guiling Sun
Jul 26, 2008·Reviews in Endocrine & Metabolic Disorders·B S KasinathD Feliers
Nov 28, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gang Niu, Xiaoyuan Chen
Jan 16, 2014·Cognitive Neurodynamics·Shuiming CaiZengrong Liu
Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chao ZhangXu Zhang
Apr 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Imran BhattiMichael Larvin
Jun 8, 2011·Endocrine Pathology·Milani SivapragasamKalman Kovacs
Dec 15, 2011·Molecular Neurobiology·Belinda J Goldie, Murray J Cairns
May 3, 2012·Molecular Neurobiology·Charlotte AngersteinUwe Klaus Zettl
Aug 23, 2011·Journal of Biosciences·Ashwani JhaRavi Shankar
Jun 19, 2010·Journal of Cardiovascular Translational Research·Sathyamangla V Naga Prasad, Sadashiva S Karnik

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