Mechanisms of pressure-diuresis and pressure-natriuresis in Dahl salt-resistant and Dahl salt-sensitive rats.

BMC Physiology
Daniel A Beard, Muriel Mescam

Abstract

Data on blood flow regulation, renal filtration, and urine output in salt-sensitive Dahl S rats fed on high-salt (hypertensive) and low-salt (prehypertensive) diets and salt-resistant Dahl R rats fed on high-salt diets were analyzed using a mathematical model of renal blood flow regulation, glomerular filtration, and solute transport in a nephron. The mechanism of pressure-diuresis and pressure-natriuresis that emerges from simulation of the integrated systems is that relatively small increases in glomerular filtration that follow from increases in renal arterial pressure cause relatively large increases in urine and sodium output. Furthermore, analysis reveals the minimal differences between the experimental cases necessary to explain the observed data. It is determined that differences in renal afferent and efferent arterial resistances are able to explain all of the qualitative differences in observed flows, filtration rates, and glomerular pressure as well as the differences in the pressure-natriuresis and pressure-diuresis relationships in the three groups. The model is able to satisfactorily explain data from all three groups without varying parameters associated with glomerular filtration or solute transport in the nephr...Continue Reading

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Citations

May 24, 2014·PLoS Computational Biology·Klas H PettersenStig W Omholt
Mar 22, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Ioannis Sgouralis, Anita T Layton
May 4, 2015·Acta Biotheoretica·Julie Fontecave-Jallon, S Randall Thomas
May 27, 2017·CPT: Pharmacometrics & Systems Pharmacology·K M Hallow, Y Gebremichael
Feb 21, 2014·F1000Research·Daniel A BeardScott M Bugenhagen
Sep 14, 2018·Biological cybernetics·Maria-Veronica CiocanelMette S Olufsen
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Feb 21, 2014·F1000Research·Daniel A BeardScott M Bugenhagen
Sep 22, 2018·Journal of Applied Physiology·Samuel A KosinskiDaniel A Beard
Nov 26, 2018·Computers in Biology and Medicine·Jessica Leete, Anita T Layton

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