Mechanisms of programmed cell death signaling in hair cells and support cells post-electrode insertion trauma

Acta Oto-laryngologica
Adrien EshraghiJeenu Mittal

Abstract

Programmed cell death (PCD) initially starts in the support cells (SCs) after electrode insertion trauma (EIT), followed by PCD in hair cells (HCs). Activation of caspase-3 was observed only in SCs. Protecting both SCs and HCs with selective otoprotective drugs at an early stage post implantation may help to preserve residual hearing. Cochlear implant EIT can initiate sensory cell losses via necrosis and PCD within the organ of Corti, which can lead to a loss of residual hearing. PCD appears to be a major factor in HC loss post-EIT. The current study aimed to: (1) determine the onset of PCD in both SCs and HCs within the traumatized organ of Corti; and (2) identify the molecular mechanisms active within the HCs and SCs that are undergoing PCD. Adult guinea pigs were assigned to one of two groups: (1) EIT and (2) unoperated contralateral ears as controls. Immunostaining of dissected organ of Corti surface preparations for phosphorylated-Jun, cleaved caspase-3, and 4-hydroxy-2,3-nonenal (HNE) were performed at 6, 12, and 24 h post-EIT and for contralateral control ears. At 6 h post-EIT the SCs immunolabeled for the presence of phosphorylated-Jun and activated caspase-3. Phosphorylated p-Jun labeling was observed at 12 h in both t...Continue Reading

References

Mar 5, 2003·The Laryngoscope·Adrien A EshraghiThomas J Balkany
Aug 13, 2004·Brain Research·Daisuke YamashitaJosef M Miller
May 14, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Adrien A EshraghiThomas R Van De Water
Nov 18, 2005·Neuroscience Letters·Tatsuya YamasobaMitsuya Suzuki
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuela Lahne, Jonathan E Gale
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adrien A EshraghiChhavi Gupta
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adrien A EshraghiRonen Nazarian
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Esperanza BasThomas R Van de Water

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Citations

Feb 9, 2016·Acta Oto-laryngologica·Adrien A EshraghiJeenu Mittal
May 13, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mun Young ChangJun Ho Lee
Mar 8, 2018·Acta Oto-laryngologica·Joshua A TillingerAdrien A Eshraghi
Aug 8, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Renato TorresYann Nguyen
Oct 17, 2018·The Laryngoscope·Alvin deTorresMichael Hoa
Apr 17, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Rahul MittalAdrien A Eshraghi
May 6, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Magdalena SosnaPiotr H Skarżyński
Jan 18, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Takefumi KamakuraJoseph B Nadol
Dec 2, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Renato TorresYann Nguyen
Dec 12, 2019·Frontiers in Cellular Neuroscience·Adrien A EshraghiJeenu Mittal
Jan 1, 2020·Laryngoscope Investigative Otolaryngology·Megan J FoggiaMarlan R Hansen
Jul 1, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christopher R KaufmannMarlan R Hansen
May 25, 2021·Metabolomics : Official Journal of the Metabolomic Society·Michel KatherArne Liebau
Jun 8, 2021·Frontiers in Neurology·Magdalena Sosna-DuranowskaHenryk Skarzynski
Jul 27, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Douglas M BennionMarlan R Hansen

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