PMID: 41537Sep 1, 1979

Mechanisms of prolongation of pre-ejection period in patients with left ventricular disease

British Heart Journal
W Chen, D G Gibson

Abstract

In order to determine the mechanism underlying prolongation of the pre-ejection period in patients with left ventricular disease, 11 patients with congestive cardiomyopathy and 29 with coronary artery disease, 10 of whom were taking beta-adrenergic blocking drugs, were studied non-invasively. Recordings of carotid pulse, and apex, phono-, and echocardiogram were obtained. In the absence of treatment with beta-blocking drugs, prolongation of pre-ejection period correlated closely with incoordinate left ventricular wall movement during isovolumic contraction assessed from simultaneous apex and echocardiograms. There was no correlation between pre-ejection period index (PEPI) and end-diastolic dimension and PEPI correlated poorly with fractional shortening and peak Vcf. A PEPI of greater than 140 ms was associated with incoordinate contraction in all but one case, and of less than 140 ms with normal contraction in all. Therapeutic doses of beta-blocking drugs caused prolongation of PEPI to a greater extent than would have been predicted from wall movement during isovolumic contraction. Incoordinate left ventricular contraction and a negative inotropic effect both therefore prolong PEPI, but by different mechanisms, whose effects c...Continue Reading

References

Apr 1, 1985·British Heart Journal·A Smalcelj, D G Gibson
Oct 1, 1981·British Heart Journal·L M ShapiroD G Beevers
Sep 1, 1980·British Heart Journal·L M ShapiroJ Mackinnon
Mar 19, 2008·Basic Research in Cardiology·Janny BøkenesOle M Sejersted
Jul 25, 2015·IEEE Transactions on Bio-medical Engineering·David Da HeCharles G Sodini
Nov 1, 1986·Clinical Cardiology·M De ScalziP Cinelli

Citations

Jul 11, 1975·Circulation·S J ShubrooksJ W Harthorne
May 1, 1976·British Heart Journal·R Seabra-GomesD J Parker
Feb 1, 1970·The American Journal of the Medical Sciences·D HuntG Hoffmann
Feb 1, 1973·British Heart Journal·D G Gibson
Mar 1, 1974·Circulation·J R BurgJ Metcalfe
Feb 1, 1968·Circulation·A M WeisslerC D Schoenfeld
Mar 1, 1969·Diseases of the Chest·R C TaraziH P Dustan
Apr 1, 1969·The American Journal of Cardiology·A M WeisslerC D Schoenfeld
Jan 1, 1956·The American Journal of Physiology·R F RUSHMER
Jan 1, 1963·Cardiologia : bollettino della Società italiana di cardiologia·V JEZEK

Related Concepts

Cardiomyopathy, Familial Idiopathic
Myocardial Contraction
GRN gene
Coronary Artery Disease
Left Ventricular Structure
Ventricular Dysfunction, Left
Contraction (Finding)
Granulin
Systole
Coronary Arteriosclerosis

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