Mechanisms of protein folding

European Biophysics Journal : EBJ
Ylva IvarssonStefano Gianni

Abstract

Understanding the mechanism by which a polypeptide chain folds into its native structure is a central problem of modern biophysics. The collaborative efforts of experimental and theoretical studies recently raised the tantalizing possibility to define a unifying mechanism for protein folding. In this review we summarize some of these intriguing advances and analyze them together with a discussion on the new findings concerning the so-called downhill folding.

References

Apr 1, 1976·Nature·M Karplus, D L Weaver
Oct 29, 1991·Biochemistry·S E Jackson, A R Fersht
Jan 1, 1988·Proteins·D BashfordD L Weaver
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A R Fersht
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·T Kiefhaber
Apr 1, 1994·Protein Science : a Publication of the Protein Society·M Karplus, D L Weaver
Jan 1, 1996·Folding & Design·J N OnuchicP G Wolynes
Jan 1, 1997·Annual Review of Physical Chemistry·J N OnuchicP G Wolynes
Nov 21, 1997·Nature·V MuñozW A Eaton
Aug 26, 1998·Folding & Design·S E Jackson
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J SabelkoM Gruebele
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·O BieriT Kiefhaber
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A R Fersht
Aug 10, 2000·Nature Structural Biology·E L McCallisterD Baker
Aug 10, 2000·Nature Structural Biology·C NishimuraP E Wright
Sep 20, 2001·Journal of the American Chemical Society·C Y HuangF Gai
Sep 29, 2001·Journal of Molecular Biology·S A GorskiS E Radford
Mar 5, 2002·Nature Structural Biology·Andrew P CapaldiSheena E Radford
Jun 8, 2002·Journal of Molecular Biology·Lisa J LapidusJames Hofrichter
Oct 9, 2002·Nature Structural Biology·Magnus LindbergMikael Oliveberg
Nov 21, 2002·Journal of Molecular Biology·Bryan A KrantzTobin R Sosnick
Dec 10, 2002·Proteins·Stephen J Hagen
Dec 14, 2002·Science·Maria M Garcia-MiraVictor Muñoz
Dec 19, 2002·Journal of Molecular Biology·Ignacio E Sánchez, Thomas Kiefhaber
Jan 9, 2003·Trends in Biochemical Sciences·Valerie Daggett, Alan R Fersht
Jul 2, 2003·Nature Structural Biology·Caroline F WrightJane Clarke
Jul 16, 2003·Journal of Molecular Biology·Stefano GianniHeinrich Roder
Aug 30, 2003·Science·Everett A LipmanWilliam A Eaton
Sep 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·C B ANFINSENF H WHITE
Oct 30, 2003·Journal of Molecular Biology·Ugo MayorAlan R Fersht
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stefano GianniAlan R Fersht
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Per JemthAlan R Fersht
Apr 23, 2004·Current Opinion in Structural Biology·Jan KubelkaWilliam A Eaton
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peter G Wolynes

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Citations

Oct 23, 2009·Biochemistry·Kan XiongSanford A Asher
Apr 16, 2009·Cellular and Molecular Life Sciences : CMLS·Tse Siang Kang, R Manjunatha Kini
Jul 5, 2017·Macromolecular Rapid Communications·Tanja K ClausChristopher Barner-Kowollik
Sep 16, 2009·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Patrícia F N Faísca
Mar 26, 2010·Physical Chemistry Chemical Physics : PCCP·Feng LiuMartin Gruebele
Apr 2, 2018·The Journal of Chemical Physics·Yoshihiko TokunagaNobuyuki Matubayasi
Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·Carlos H T P Silva, Carlton A Taft
Dec 5, 2020·Scientific Reports·Rinaldo GraziosoGaetano Malgieri
Jul 21, 2012·Journal of the American Chemical Society·Jungkweon ChoiTetsuro Majima

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