Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha

Circulation Research
D C HockingA Johnson

Abstract

We tested the hypothesis that human recombinant tumor necrosis factor-alpha (TNF) promotes pulmonary edema by neutrophil-dependent effects on the pulmonary vasculature. The isolated guinea pig lung was perfused with phosphate-buffered Ringer's solution with or without human neutrophils. The infusion of neutrophils (9 x 10(6) total) into lungs isolated after the in vivo administration of TNF (3.2 x 10(5) units/kg) resulted in weight gain (+1.951 +/- 0.311 g versus -0.053 +/- 0.053 g in control) and an increase in the lung (wet-dry)-to-dry weight ratio (8.3 +/- 0.5 versus 6.0 +/- 0.2 in control), indicating the formation of pulmonary edema. The neutrophil-dependent pulmonary edema induced by TNF was associated with a combination of increased capillary permeability (capillary filtration coefficient [Kf,c], 0.170 +/- 0.048 g/min/cm H2O/g at 30 minutes versus 0.118 +/- 0.008 g/min/cm H2O/g at baseline) and increased pulmonary capillary pressure (Ppc, 12.8 +/- 0.8 cm H2O at 60 minutes versus 6.0 +/- 0.3 cm H2O at baseline). The Ppc increase was mediated by thromboxane A2 (TXA2) because the TXA2 synthetase inhibitor Dazoxiben (0.5 mM) prevented the effect (Ppc, 6.7 +/- 0.6 cm H2O at 60 minutes with Dazoxiben), and thromboxane B2 (TXB2...Continue Reading

References

Jul 1, 1977·The Anatomical Record·W G ForssmannD W Fawcett
Dec 14, 1978·Cell and Tissue Research·D E ScottG Krobisch-Dudley
Jun 1, 1989·Journal of Applied Physiology·A SakaiN F Voelkel
Oct 1, 1989·The American Review of Respiratory Disease·C E PattersonR A Rhoades
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Jun 30, 1986·Biochemical and Biophysical Research Communications·M TsujimotoG Weissmann
Jun 1, 1988·The American Review of Respiratory Disease·K E StephensT A Raffin
Nov 1, 1988·The American Review of Respiratory Disease·K E StephensT A Raffin
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I C KettelhutA L Goldberg
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J HorvathA B Malik
Apr 14, 1986·Biochemical and Biophysical Research Communications·P R BachwichS L Kunkel
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
May 1, 1987·The Journal of Clinical Investigation·S W ChangN F Voelkel
Mar 1, 1986·The Journal of Experimental Medicine·P P Nawroth, D M Stern
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J R GambleM A Vadas
Feb 1, 1981·Biochemical Society Transactions·H Jamil, J B Clarke
Jul 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J H LinehanD A Rickaby
Jan 1, 1981·Infection and Immunity·M R Ruff, G E Gifford

❮ Previous
Next ❯

Citations

Dec 1, 1993·Journal of Cellular Physiology·C W MaranoJ M Mullin
Apr 1, 1995·Immunopharmacology·G P PessinaV Bocci
Jan 1, 1993·Veterinary Immunology and Immunopathology·L W PaceW H Fales
Feb 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Thomas S MaxeyAllan Doctor
Dec 29, 1998·Respiration Physiology·L PesceR Sanchez de León
Mar 23, 2000·International Journal of Immunopharmacology·N OhtakeS Hayashi
Mar 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G P PessinaV Bocci
Apr 30, 1999·Transplantation·K J OldhaferR Pichlmayr
Apr 12, 2003·Critical Care Medicine·Carmine G De PasqualeAndrew D Bersten
Oct 1, 1996·The Journal of Pharmacy and Pharmacology·G P PessinaV Bocci
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Jul 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ronen SumaginIngrid H Sarelius
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·M F TsanC Y Lee
Apr 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Irina PetracheAlexander D Verin
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro GonHugh Rosen
Mar 1, 1995·Intensive Care Medicine·S Fujishima, N Aikawa
Jul 1, 1992·Chest·E C RosenowR J Pisani
Feb 15, 2011·European Journal of Pharmacology·Amy Barton-PaiArnold Johnson
Aug 1, 2014·Thrombosis and Haemostasis·B Marcos-RamiroJ Millán
Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Filip R RegaDirk E M Van Raemdonck
Jun 20, 2014·Journal of Magnetic Resonance Imaging : JMRI·Flavio CarinciPeter M Jakob
Aug 28, 2014·The International Journal of Biochemistry & Cell Biology·Li-Xia XuZhi-Song Zhang
Dec 29, 2010·Journal of Cardiovascular Disease Research·Guang YangRudolf Lucas
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kishor Devalaraja-NarashimhaBabu J Padanilam
Jun 1, 1995·Journal of Cardiac Failure·E CavusogluM Klapholz
Apr 6, 2004·Clinics in Chest Medicine·Andrew H Limper
Nov 1, 1993·Toxicologic Pathology·H R AmouzadehL E Stein
Oct 31, 1996·Annals of the New York Academy of Sciences·L F NevilleR Rabinovici
Dec 16, 2006·Congestive Heart Failure·John W Petersen, G Michael Felker
Apr 13, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Maria Iris HermannsCharles James Kirkpatrick
Dec 24, 2005·Physiological Reviews·Dolly Mehta, Asrar B Malik
Sep 1, 1995·Journal of Toxicology and Environmental Health·D C KuhnL M Demers
Jan 1, 1992·Journal of Toxicology and Environmental Health·D C Kuhn, L M Demers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.