Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans

Journal of Fungi
Steven T Denham, Jessica C S Brown

Abstract

Cryptococcus neoformans is a common environmental saprophyte and human fungal pathogen that primarily causes disease in immunocompromised individuals. Similar to many environmentally acquired human fungal pathogens,C. neoformansinitiates infection in the lungs. However, the main driver of mortality is invasive cryptococcosis leading to fungal meningitis. AfterC. neoformansgains a foothold in the lungs, a critical early step in invasion is transversal of the respiratory epithelium. In this review, we summarize current knowledge relating to pulmonary escape. We focus on fungal factors that allowC. neoformansto disseminate from the lungs via intracellular and extracellular routes.

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Citations

Dec 26, 2019·MBio·Melissa Cruz-AcuñaJamal S Lewis
Aug 9, 2020·Molecular Microbiology·Jinxing SongRongpeng Li
May 1, 2020·BMC Pulmonary Medicine·Hiroki TashiroNaoko Sueoka-Aragane
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Nov 1, 2021·FEMS Microbiology Letters·Suraya MuzafarRajendra Prasad

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