PMID: 3745698Sep 1, 1986Paper

Mechanisms of pulsus paradoxus during resistive respiratory loading and asthma

Journal of the American College of Cardiology
A S BlausteinE R McFadden

Abstract

To determine the mechanisms of pulsus paradoxus during asthma, six subjects known to have cold air bronchial hyperreactivity were studied while in a quiescent phase of their disease. All were free of significant airway obstruction at the time of study. After placement of an esophageal balloon to estimate intrathoracic pressure, the subjects were assessed during quiet breathing, resistive airway loading and then during a stable period of airway obstruction induced by cold air. Steady state left ventricular volume and performance were measured using radionuclide ventriculography; right ventricular volume was calculated from the stroke volume ratio and right ventricular ejection fraction. Cardiac cycles were segregated according to their occurrence in inspiration or expiration using a flow signal from a pneumotachograph. Combined inspiratory and expiratory resistance produced pulsus paradoxus and changes in esophageal pressure that were similar to those during asthma and significantly greater than those during quiet breathing. These changes were accompanied by decreases in left ventricular diastolic volume and stroke volume during inspiration, and increases in these variables during expiration; right ventricular volume and stroke ...Continue Reading

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Citations

Aug 31, 2012·Journal of Clinical Monitoring and Computing·Alain F Broccard
Jun 1, 1995·Journal of Sleep Research·O Marrone, M R Bonsignore
Aug 7, 2009·Theoretical Biology & Medical Modelling·Deepa RamachandranJohn W Clark
Mar 8, 2013·PloS One·Chang-yang XingYun-you Duan
Sep 25, 2014·Echocardiography·Bahaa M FadelGiovanni Di Salvo
Jan 10, 2018·American Journal of Respiratory and Critical Care Medicine·David B KantorJoel N Hirschhorn
Jun 7, 2018·The Clinical Respiratory Journal·Malay SarkarKushal Dogra
Dec 23, 2008·Epilepsia·Elson L So
Feb 26, 2020·Archives of Disease in Childhood·Sandhya G KrishnanGene Yong-Kwang Ong
Jul 30, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Mark A KliewerAnjuli R Bagley

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