Mechanisms of Radiation Bystander and Non-Targeted Effects: Implications to Radiation Carcinogenesis and Radiotherapy

Current Radiopharmaceuticals
Rasoul YahyapourVilmar Villa

Abstract

Knowledge of radiobiology is of paramount importance to be able to grasp and have an in-depth understanding of the consequences of ionizing radiation. One of the most important effects of this physical stressor's interaction to targeted and non-targeted cells, tissues and organs is on the late effects on the development of primary and secondary cancers. Thus, an in-depth understanding of the mechanisms of radiation carcinogenesis remains to be elucidated, and some studies have demonstrated or proposed a role of non-targeted effect in excess risk of cancer incidence. The non-targeted effect in radiobiology refers to a dynamic complex response in non-irradiated tissues caused by the release of presumably of clastogenic factors from irradiated cells. Although, most of these responses in non-targeted tissues have marked similarities to irradiated tissues, other studies have shown some differences. Also, the non-targeted effect has shown sex and tissue specificity that are seen in irradiated tissues too. So far, several studies have been conducted to depict mechanisms that may be involved in this phenomenon. Epigenetic dysfunctions, DNA damage and cell death are responsible for initiation of several signaling pathways that finally r...Continue Reading

Citations

Mar 6, 2018·International Journal of Radiation Biology·Masoud NajafiHamid Abdollahi
Jan 11, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R YahyapourV Villa
Aug 4, 2018·Current Molecular Pharmacology·Peyman AminiMasoud Najafi
Oct 16, 2018·Current Molecular Pharmacology·Keywan MortezaeeBagher Farhood
Dec 31, 2019·The Journal of International Medical Research·Xin-Da SongBin Liu
Dec 13, 2019·Phytotherapy Research : PTR·Milad AshrafizadehSaeed Samarghandian
Dec 17, 2019·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·O V Shemetun, M A Pilinska
Sep 12, 2018·International Journal of Environmental Research and Public Health·Ernesto BurgioLucia Migliore
May 7, 2019·Current Clinical Pharmacology·Masoud NajafiDheyauldeen Shabeeb
Mar 25, 2020·Nuclear Medicine and Molecular Imaging·Aisyah ElliyantiWirsma Arif Harahap
Jul 31, 2020·Biomedicines·Carolina Alonso-GonzálezSamuel Cos
Aug 24, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B FarhoodM Najafi
Mar 21, 2018·Military Medical Research·Rasoul YahyapourMasoud Najafi
Aug 9, 2019·Environmental Science and Pollution Research International·Tolga MercantepeFiliz Mercantepe
Jul 25, 2018·British Journal of Cancer·Li-Jun MoPing-Kun Zhou
Jun 19, 2018·Journal of Cell Communication and Signaling·Bagher FarhoodMasoud Najafi
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Jinlong WeiXin Jiang
Oct 27, 2018·Current Clinical Pharmacology·Keywan MortezaeeBagher Farhood
Jan 1, 2021·Frontiers in Cell and Developmental Biology·Marina KonkovaSvetlana Kostyuk
Feb 4, 2021·Environmental Science and Pollution Research International·Yonglin ChenLan Yi
Dec 3, 2020·Biology·Margalida Torrens-Mas, Pilar Roca
May 1, 2021·International Journal of Molecular Sciences·Simonetta PazzagliaMariateresa Mancuso
Jun 8, 2021·Archives of Biochemistry and Biophysics·Xiao FuMasoud Najafi
Jun 20, 2021·Life Sciences·Sahar SheikholeslamiBagher Farhood

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