Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db/db mice with acute regional ischemia-reperfusion injury.

Scientific Reports
Chung-Chuan ChouPo-Cheng Chang

Abstract

Studies have demonstrated that diabetic (db/db) mice have increased susceptibility to myocardial ischemia-reperfusion (IR) injury and ventricular tachyarrhythmias (VA). We aimed to investigate the antiarrhythmic and molecular mechanisms of ranolazine in db/db mouse hearts with acute IR injury. Ranolazine was administered for 1 week before coronary artery ligation. Diabetic db/db and control db/+ mice were divided into ranolazine-given and -nongiven groups. IR model was created by 15-min left coronary artery ligation and 10-min reperfusion. In vivo electrophysiological studies showed that the severity of VA inducibility was higher in db/db mice than control (db/ +) mice. Ranolazine suppressed the VA inducibility and severity. Optical mapping studies in Langendorff-perfused hearts showed that ranolazine significantly shortened action potential duration, Cai transient duration, Cai decay time, ameliorated conduction inhomogeneity, and suppressed arrhythmogenic alternans induction. Western blotting studies showed that the expression of pThr17-phospholamban, calsequestrin 2 and voltage-gated sodium channel in the IR zone was significantly downregulated in db/db mice, which was ameliorated with ranolazine pretreatment and might play ...Continue Reading

References

Oct 1, 1989·Journal of Molecular and Cellular Cardiology·U LimbrunoM Mariani
May 1, 1997·The Journal of Physiology·C A Ward, W R Giles
Aug 13, 1999·The American Journal of Physiology·S P JonesD J Lefer
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D J LeferA M Lefer
Oct 27, 2001·Circulation Research·S J KimS F Vatner
Dec 4, 2003·Biophysical Journal·Y ShiferawA Karma
Jun 18, 2005·Acta Pharmacologica Sinica·Ji-Hua MaPei-Hua Zhang
Aug 23, 2005·American Journal of Physiology. Heart and Circulatory Physiology·James J M GreerDavid J Lefer
Aug 14, 2009·The Journal of Pharmacology and Experimental Therapeutics·J Andrew WasserstromGary L Aistrup
Sep 22, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Arvinder K DhallaRobert A Kloner
Nov 3, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Parisa RahnemaAnders Nygren
Mar 23, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchLuiz Belardinelli
Jul 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammed AldakkakDavid F Stowe
Jan 19, 2013·Cardiovascular Diabetology·Kristine Boisen OlsenMorten Schak Nielsen
Oct 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Mohammad RajabJonas B Galper
Jan 28, 2014·European Journal of Heart Failure·Carlo G TocchettiNicola Maurea
Sep 1, 2014·Journal of Molecular and Cellular Cardiology·Can M SagBernhard Unsöld
Sep 11, 2014·Cell Calcium·Laetitia PereiraAna María Gómez
Aug 27, 2017·Pacing and Clinical Electrophysiology : PACE·Chung-Chuan ChouPo-Cheng Chang
Jun 22, 2018·Pacing and Clinical Electrophysiology : PACE·Po-Cheng ChangChung-Chuan Chou
Sep 9, 2018·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hidehira FukayaLance D Wilson

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Citations

Aug 13, 2021·Frontiers in Pharmacology·Christopher R VeitchJeffrey R Erickson

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