Mechanisms of rDNA Copy Number Maintenance

Trends in Genetics : TIG
Jonathan O NelsonYukiko Yamashita

Abstract

rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNA genes are arranged in large stretches of tandem repeats, forming loci that are highly susceptible to copy loss due to their repetitiveness and active transcription throughout the cell cycle. Despite this inherent instability, rDNA copy number is generally maintained within a particular range in each species, pointing to the presence of mechanisms that maintain rDNA copy number in a homeostatic range. In this review, we summarize the current understanding of these maintenance mechanisms and how they sustain rDNA copy number throughout populations.

References

Jan 1, 1979·Nucleic Acids Research·J KlootwijkR J Planta
Oct 9, 1979·Journal of Molecular Biology·T YaguraM Muramatsu
May 5, 1977·Journal of Molecular Biology·F GrazianiS Gargano
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E M Lyckegaard, A G Clark
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D J Komma, S A Endow
Apr 1, 1985·Genetics·R S Hawley, K D Tartof
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R S HawleyA E Zitron
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K D Tartof
Jan 1, 1974·Chromosoma·A S HendersonK C Atwood
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P K Wellauer, I B Dawid
Dec 15, 1972·Nature·R Johnson, B L Strehler
Jun 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·F M Ritossa
Mar 14, 1969·Journal of Molecular Biology·E SchweizerH O Halvorson
May 1, 1983·Genetics·R S Hawley, K D Tartof
Dec 1, 1984·Genetics·S A EndowK C Atwood
Jan 1, 1980·Molecular & General Genetics : MGG·C MalvaG Gargiulo
Jan 1, 1980·Annual Review of Biochemistry·E O Long, I B Dawid
Dec 1, 1993·Genetical Research·D J KommaS A Endow
Jan 15, 1998·Cell·D A Sinclair, L Guarente
Mar 24, 1998·Yeast·R J Planta
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S SmithJ D Boeke
Jun 5, 2003·Genes & Development·Yasushi TakeuchiTakehiko Kobayashi
Sep 6, 2005·Science·Takehiko Kobayashi, Austen R D Ganley

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Citations

Oct 10, 2020·Genome Research·Ariadna Picart-PicoloFrédéric Pontvianne
Nov 3, 2020·Frontiers in Plant Science·Kateřina Havlová, Jiří Fajkus
Mar 6, 2021·Molecular Microbiology·Francisco Alejandro Lagunas-RangelRosa María Bermúdez-Cruz
Apr 8, 2021·PLoS Genetics·José E Pérez-OrtínJosé García-Martínez
May 11, 2021·Frontiers in Molecular Biosciences·Marina Barba-AliagaJosé E Pérez-Ortín
Apr 23, 2021·Molecular Biology and Evolution·Kyle E McElroyMaurine Neiman
Aug 28, 2021·Genes·Jiachen XuanElaine Sanij
Oct 28, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David Haig

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