PMID: 375000Jan 16, 1979Paper

Mechanisms of recombination by the RecBC and the RecF pathways following conjugation in Escherichia coli K12

Molecular & General Genetics : MGG
S K Mahajan, A R Datta

Abstract

The recombinational processes directed by the RecBC and the RecF pathways following conjugation in E. coli have been compared. The viable recombinant products of the RecF pathway show a higher incidence of mismatch correction, higher percentage of heterogeneous clones produced by single ex-conjugants and a much slower rate of integration and segregation compared to the RecBC pathway. There are reasons to suspect that the product of recB and recC genes may be necessary for conversion of the single stranded donor DNA in the zygote to double stranded DNA. Theoretical considerations suggest that an exchange involving only one strand of DNA may be a much slower process, with more stringent homology requirement for the entire exchanged segment, than a double strand exchange of a comparable length; the latter should be much faster, with stringent homology requirements for only the terminal regions of the exchanged segments. It is suggested that the RecF pathway mainly mediates replacement of relatively long stretches of single strands of recipient DNA by the corresponding strands of donor DNA while the RecBC pathway mediates exchange of mostly double stranded DNA between the donor and the recipient; in addition, the RecBC pathway may ...Continue Reading

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Citations

Jan 1, 1981·Molecular & General Genetics : MGG·S E BreslerV A Lanzov
Jan 1, 1983·Molecular & General Genetics : MGG·R G Lloyd, A Thomas
Jan 1, 1983·Molecular & General Genetics : MGG·R G LloydC Prescott
Jan 1, 1984·Molecular & General Genetics : MGG·M MastersC M Henry
Jan 1, 1984·Molecular & General Genetics : MGG·R G LloydC E Shurvinton
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R Kolodner
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·S D Hall, R D Kolodner
Jan 1, 1994·Molecular Microbiology·R KolodnerC Luisi-DeLuca
Aug 1, 1980·Journal of Bacteriology·W P HoekstraE M Zuidweg
Nov 1, 1990·Journal of Bacteriology·T J Griffin, R D Kolodner
Sep 1, 1994·Microbiological Reviews·S C KowalczykowskiW M Rehrauer
Dec 1, 1990·Microbiological Reviews·R R Meyer, P S Laine

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