Mechanisms of reflex bradycardia and hypotension by metabolites of arachidonic acid in the cat

British Journal of Pharmacology
T H HintzeM J Panzenbeck

Abstract

In the cat, intravenous injections of arachidonic acid or prostaglandin (PG)F2 alpha caused significant reductions in mean arterial pressure and heart rate which were eliminated or significantly lessened, respectively, by previous administration of indomethacin. The bradycardia to intravenous prostacyclin (PGI2) was unaffected by indomethacin. In cats with bilateral ligation of the carotid arteries to eliminate competition between systemic baroreflexes and cardiopulmonary reflexes, PGI2, PGF2 alpha and arachidonic acid caused significantly greater hypotension and bradycardia than in cats with intact carotid baroreflexes. The bradycardia to PGI2, PGF2 alpha and arachidonic acid was eliminated by bilateral vagal section or atropine. PGE1, PGE2 and nitroprusside caused dose-related falls in mean arterial pressure and a small tachycardia. In a small group of cats (7 of 67) nitroprusside also caused a reduction in heart rate which was eliminated by indomethacin. We conclude that the reflex bradycardia to PGF2 alpha, like that to arachidonic acid is, at least in part, the result of the stimulation of synthesis of another prostaglandin, most likely PGI2.

References

Jun 29, 1978·Nature·S MoncadaJ R Vane
May 1, 1979·European Journal of Pharmacology·E A De DeckereF Ten Hoor
Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T H HintzeG Kaley
Mar 1, 1979·European Journal of Pharmacology·K M MullaneJ R Vane
Jul 28, 1978·Biochemical and Biophysical Research Communications·S I MurotaY Mori
Mar 1, 1977·Circulation Research·T H Hintze, G Kaley
Mar 1, 1976·British Journal of Pharmacology·M C Koss, J Nakano
Oct 1, 1971·Circulation Research·T Takeuchi, J W Manning
Nov 10, 1974·Prostaglandins·M C Koss, J Nakano
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·M C Koss, J Nakano
Nov 1, 1973·European Journal of Pharmacology·M C KossJ Nakano
Sep 1, 1971·British Journal of Pharmacology·B Levy, H R Lindner
Dec 1, 1965·Acta Physiologica Scandinavica·B Folkow, E H Rubinstein
Jan 1, 1980·The American Journal of Cardiology·E MorcillioB Pitt
Mar 1, 1981·The Journal of Clinical Investigation·R I LevinK Tack-Goldman
Sep 1, 1981·Cardiovascular Research·T H HintzeG Kaley
Jan 1, 1982·British Journal of Pharmacology·M ChiavarelliK M Mullane
Jan 1, 1953·Circulation Research·C HEYMANSG VAN DEN HEUVEL-HEYMANS

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Citations

Jun 1, 1985·Journal of the American College of Cardiology·D RobertsonR M Robertson
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S Y SunH D Schultz

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