Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175

British Journal of Pharmacology
M HernándezU Simonsen

Abstract

1. The present study was designed to investigate the effects and mechanisms of relaxation induced by the nitric oxide (NO) donor, GEA 3175 (a 3-aryl-substituted oxatriazole derivative) on bovine bronchioles (effective lumen diameter 200-800 microm) suspended in microvascular myographs for isometric tension recording. 2. In segments of bovine bronchioles contracted to 5-hydroxytryptamine, GEA 3175 (10(-8)-10(-4) M) induced concentration-dependent reproducible relaxations. These relaxations were slow in onset compared to other NO-donors such as 3-morpholinosydonimine-hydrochloride (SIN-1) and S-nitroso-N-acetylpenicillamine (SNAP). 3. In 5-hydroxytryptamine-contracted preparations the order of relaxant potency (pD2) was: salbutamol (7.80) > GEA 3175 (6.18) > SIN-1 (4.90) > SNAP (3.55). In segments contracted to acetylcholine, the relaxant responses were reduced and GEA 3175 relaxed the bronchioles with pD2 = 4.41 +/- 0.12 and relaxations of 66 +/- 10% (n = 4), while SNAP and salbutamol caused relaxations of 19 +/- 6% (n = 4) and 27 +/- 6% (n = 8) at the highest concentration used, respectively. 4. Oxyhaemoglobin (10(-5) M), the scavenger of nitric oxide, caused rightward shifts of the concentration-relaxation curves to GEA 3175 a...Continue Reading

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Citations

May 19, 2005·European Journal of Pharmacology·Britt ElmedalUlf Simonsen
Aug 11, 1998·European Journal of Pharmacology·P RecioA García-Sacristán
Sep 24, 2002·Pharmacology & Therapeutics·B J Nevin, K J Broadley
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Jun 27, 2013·Indian Journal of Pharmaceutical Sciences·S R DeshpandeK V Pai
Jan 12, 2007·Cardiovascular Drug Reviews·Britt Elmedal LaursenUlf Simonsen
Aug 4, 2004·European Journal of Pharmacology·Anna K Asplund PerssonMagnus Grenegård
Sep 8, 2016·Pulmonary Pharmacology & Therapeutics·Vítor S FernandesMedardo Hernández
Apr 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Vincent LagenteCharles Advenier
Feb 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christel KroigaardUlf Simonsen
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk

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