Jul 1, 1989

Mechanisms of reproduction by exogenous RNA of specific effects of biologically active substances

Farmakologiia i toksikologiia
A V Smirnov

Abstract

The specific effects of the biologically active substances conditioned by the induction of RNA and protein synthesis in certain organs are reproduced by RNA molecules from the organs after their introduction into the recipient organism. The most probable mechanisms of the action of exogenous RNA is the specific depression of genes in the recipient target cells at the interaction of RNA with the regulatory proteins of chromatin. In some cases the inclusion of exogenous RNA by means of reverse transcriptase into the genome++ of the recipient cells with their subsequent transcription is considered to be a possible mechanism. First of all it is the representatives of the class of low molecular nuclear RNA that claim to the role of the active principle of the preparations of exogenous RNA. The experimental findings suggest the use of exogenous RNA for the analysis of complex effects of the biologically active substances.

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Mentioned in this Paper

Protein Biosynthesis
Organ
Organism
Target Cell Count
Chromatin Location
Regulatory Protein
RNA-Directed DNA Polymerase
RNA, Nuclear
RNA
Leptocyte

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