PMID: 6707470Apr 1, 1984

Mechanisms of resistance of staphylococci grown in plasma to polymorph bactericidins

The Journal of Hygiene
D O Kolawole

Abstract

The mechanisms whereby staphylococcal strains grown in plasma assume increased resistance to polymorph bactericidins were investigated. Observations reported here showed that cultural conditions could determine the path of conversion to resistance. Staphylococcal strains and mutants lacking either free coagulase or clumping factor or both all showed enhanced resistance after 10 h incubation in plasma proteins, thus giving no clear indication that these factors were involved in the interactions. In fact, prolonged incubation in bovine serum albumin (22 h) and ordinary broth medium (24 h) also resulted in increased resistance. A distinction between staphylococcal factors interacting specifically with plasma proteins and such non-specific conversions was obtained in two different ways. Stripping of a hypothetical surface protein by treatment with trypsin or 2 M potassium bromide rendered plasma- but not 24 h-broth organisms susceptible, indicating protein coating of plasma-grown organisms. Also free coagulase-positive strains and mutants incubated in plasma for 30 min were converted while those lacking both or possessing clumping factor alone were not. It therefore appears that one of the mechanisms of acquiring resistance involve...Continue Reading

Citations

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Related Concepts

Antibiotic Resistance, Microbial
Fibrin Measurement
Bromides
Derivatives
Fibrinogen
Fibrinogen Assay
Potassium
ALB
Genus staphylococcus
Serum Proteins

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