Mechanisms of resistance/susceptibility to murine encephalitozoonosis

Parasite Immunology
J J LiuJ A Shadduck

Abstract

Mechanisms of resistance/susceptibility to the obligate intracellular protozoan Encephalitozoon cuniculi were studied in resistant BALB/c and susceptible C57BL/6 mice. Three immunological functions were examined: the production of lymphokine(s) (LK) by T-lymphocytes, the proliferative response of spleen cells to parasite spore fragments, and the ability of splenic and thioglycollate-induced peritoneal macrophages to act as accessory cells in antigen-induced T-cell proliferation. The two strains showed differences in the time required for LK production in vitro but not in their ability to generate LK. Spore fragment-induced lymphoblastogenesis was found in spleen cells of infected BALB/c and C57BL/6 mice. There was no difference between the two strains in dose response and time of maximal response, but the magnitude of maximal response was significantly less in C57BL/6 mice. Indomethacin was found to augment the lymphoproliferative response of C57BL/6 but not BALB/c mice, suggesting that prostaglandin production may be involved in immunosuppression in C57BL/6 mice. C57BL/6 mice required more splenic adherent cells to achieve the same proliferative response as found in BALB/c mice. The ability of thioglycollate-induced peritoneal...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·N Nogueira, Z A Cohn
Jan 1, 1985·Immunology Letters·H P HughesL Hudson
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Sep 1, 1981·The Journal of Infectious Diseases·J Y NiederkornE C Schmidt
Jan 1, 1983·Advances in Experimental Medicine and Biology·S CohenT Yoshida
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K P Chang, J W Chiao

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Citations

Jan 1, 1992·Parasitology Research·V LecomteF Santoro
Aug 29, 2006·Veterinary Immunology and Immunopathology·L E Rodriguez-TovarJ Sheppard
Nov 30, 2004·Veterinary Parasitology·E S DidierP J Didier
Aug 17, 2005·Arquivos de neuro-psiquiatria·Maria Anete Lallo, Eduardo Fernandes Bondan
Dec 12, 2003·Phytotherapy Research : PTR·D GarcíaF M Ubeira
Dec 1, 2011·FEMS Microbiology Reviews·Kaya Ghosh, Louis M Weiss

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