PMID: 8594224Oct 1, 1995Paper

Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis

Journal of Neurotrauma
B K SiesjöM L Smith

Abstract

The objective of this article is to amalgamate previous results into a speculative synthesis that sheds light on the causes of secondary brain damage following either global/forebrain or focal ischemia. The hypothesis is based on the well-founded assumption that the pathophysiology of the brain damage incurred by global or forebrain ischemia is different from that of focal ischemia. In the former, the ischemia is usually dense and of brief duration and, provided that reperfusion is adequate, cell damage is conspicuously delayed, mostly affecting selectively vulnerable neurons. In contrast, focal ischemia is either long-lasting or permanent, and it is usually less severe, particularly in the perifocal penumbral regions. The lesion is typically pan-necrotic ("infarction"), initially affecting the focus supplied by the occluded artery, later invading the penumbra zone. Available results allow a restatement of the calcium hypothesis of cell death. In global or forebrain ischemia, calcium influx through channels gated by voltage or glutamate receptors is envisaged to trigger reactions that limit the survival of neurons during reperfusion, leading to secondary neuronal death after hours or days of survival. It can be hypothesized tha...Continue Reading

References

Jul 1, 1979·Stroke; a Journal of Cerebral Circulation·S RehncronaB K Siesjö
Feb 1, 1976·Archives of Neurology·P SafarE M Nemoto
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GillH Hagberg
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I A Silver, M Erecińska
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P AndinéH Hagberg
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B Nellgård, T Wieloch
Feb 29, 1992·Lancet·W Pulsinelli
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Jan 1, 1992·Annals of Neurology·S OrreniusP Nicotera
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Apr 1, 1992·Stroke; a Journal of Cerebral Circulation·H MemezawaB K Siesjö
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·B KaplanW Pulsinelli
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C N OliverR A Floyd
May 1, 1990·The Journal of General Physiology·I A Silver, M Erecińska
Oct 1, 1990·Stroke; a Journal of Cerebral Circulation·W FujieA Tamura
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LundgrenB K Siesjö
Jan 1, 1988·Annals of the New York Academy of Sciences·B K Siesjö
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Jan 1, 1989·Free Radical Research Communications·I E BlasigH Loewe
Jan 1, 1989·Chemico-biological Interactions·H A Kontos
Dec 1, 1989·Stroke; a Journal of Cerebral Circulation·M D Ginsberg, R Busto
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M CardellT Wieloch
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KozukaB K Siesjö
Dec 1, 1986·Circulation Research·R C KukrejaE F Ellis
Feb 1, 1988·Acta Neurologica Scandinavica·M Nedergaard
Jan 1, 1988·Acta Neurologica Scandinavica·J M López-VegaJ Berciano
May 24, 1988·Brain Research·M Nedergaard, A J Hansen
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J K DeshpandeT Wieloch
Feb 1, 1987·Journal of the Neurological Sciences·K A HossmannB Grosse Ophoff
Jan 1, 1985·Physiological Reviews·A J Hansen
Dec 1, 1973·Archives of Neurology·K A Hossmann, P Kleihues

❮ Previous
Next ❯

Citations

Sep 25, 2002·Journal of Neuroscience Research·Rao Muralikrishna Adibhatla, J F Hatcher
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R XueS Mori
Aug 19, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Changqin LiuShenggang Sun
Aug 12, 1999·European Journal of Pharmacology·D DewarJ McCulloch
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·T J HudzikG C Palmer
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·C Lascola, R P Kraig
Oct 19, 1999·Brain Research. Brain Research Reviews·R Berger, Y Garnier
Oct 21, 2000·Journal of Neuroscience Methods·H BonatzK M Giehl
Feb 27, 2001·Neurochemistry International·J ChateilM Merle
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jasenka Mrsić-PelcićAnte Simonić
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B Pardo, P Honegger
Apr 1, 2000·Cytokine & Growth Factor Reviews·E ShohamiJ M Hallenbeck
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R HärtlG J del Zoppo
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Vorísek, E Syková
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H NawashiroJ M Hallenbeck
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R TsuchidateB K Siesjö
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T R SairanenA L Sirén
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ZhuJ Krieglstein
Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W Paschen, J Doutheil
Nov 26, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ericka L FinkR Scott Watson
Jan 28, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaaki HokariYoshinobu Iwasaki
May 10, 2007·Journal of Neurochemistry·Ludmila A VolobouevaRona G Giffard
May 4, 2012·Experimental & Translational Stroke Medicine·Thomas WestermaierRalf-Ingo Ernestus
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi-Bing OuyangRona G Giffard
Jul 12, 2003·Journal of Neurosurgery·Harold K KimelbergPaul J Feustel
Aug 30, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Yea-Ru YangShang-Ming Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.