Mechanisms of Selective Autophagy

Journal of Molecular Biology
Gabriele Zaffagnini, Sascha Martens

Abstract

Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes. Cargo specificity can be mediated by autophagic cargo receptors that specifically bind the cargo material and the autophagosomal membrane. Here we review the recent insights into the mechanisms that enable cargo receptors to confer selectivity and exclusivity to the autophagic process. We also discuss their different roles during starvation-induced and selective autophagy. We propose to classify autophagic events into cargo-independent and cargo-induced autophagosome formation events.

References

Nov 10, 1977·Nature·G E Mortimore, C M Schworer
Sep 1, 1990·The Journal of Cell Biology·J KopitzP O Seglen
Jan 1, 1966·Annual Review of Physiology·C De Duve, R Wattiaux
Jul 28, 1997·The Journal of Cell Biology·T SternsdorfH Will
Jun 30, 2001·Molecular Cell·S V ScottD J Klionsky
Dec 26, 2001·The Journal of Biological Chemistry·Guolong Zhang, Sankar Ghosh
Dec 14, 2002·Developmental Cell·Kuninori SuzukiYoshinori Ohsumi
Dec 14, 2002·Developmental Cell·Takahiro ShintaniDaniel J Klionsky
Jun 19, 2003·The Journal of Biological Chemistry·Trond LamarkTerje Johansen
Jan 1, 1962·The Journal of Cell Biology·T P ASHFORD, K R PORTER
Oct 1, 1962·The Journal of Cell Biology·A B NOVIKOFF, E ESSNER
Feb 6, 2004·The Journal of Biological Chemistry·Jun Onodera, Yoshinori Ohsumi
May 13, 2004·The Journal of Biological Chemistry·Takahiro Shintani, Daniel J Klionsky
Jun 1, 2004·Journal of Cell Science·Yukiko KabeyaTamotsu Yoshimori
Sep 2, 2004·Molecular and Cellular Biology·M Lamar SeibenhenerMarie W Wooten
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Jan 22, 2005·Molecular Biology of the Cell·Tomohiro Yorimitsu, Daniel J Klionsky
Jul 12, 2005·Nature Structural & Molecular Biology·Shahri RaasiCecile M Pickart
Feb 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kuninori SuzukiYoshinori Ohsumi
Jun 21, 2007·The Journal of Biological Chemistry·Serhiy PankivTerje Johansen
Nov 8, 2007·The Journal of Biological Chemistry·Takao HanadaYoshinori Ohsumi
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Feb 9, 2008·Histochemistry and Cell Biology·Tino KurzUlf T Brunk
Jun 6, 2008·The Journal of Biological Chemistry·Yoshinobu IchimuraMasaaki Komatsu
Oct 22, 2008·Biochimica Et Biophysica Acta·Paolo ArosioPatrizia Cavadini
Dec 9, 2008·Biochemical and Biophysical Research Communications·Takuya KageyamaYoshinori Ohsumi
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter Kijun KimJennifer Lippincott-Schwartz
Mar 3, 2009·Molecular Cell·Vladimir KirkinTerje Johansen
Mar 7, 2009·Biochimica Et Biophysica Acta·Claudine KraftMatthias Peter
Dec 17, 2009·EMBO Reports·Ivana NovakIvan Dikic

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Citations

Apr 3, 2016·Journal of Molecular Biology·James H Hurley
Sep 27, 2016·Small GTPases·Christopher A LambSharon A Tooze
Nov 24, 2016·ELife·Dorotea FracchiollaSascha Martens
Dec 14, 2016·Cell Biology and Toxicology·Mónika Lippai, Zsuzsanna Szatmári
Jan 18, 2017·Traffic·Sharon A ToozeTrina A Schroer
May 2, 2017·Annual Review of Biochemistry·Ivan Dikic
Mar 17, 2017·Annual Review of Biochemistry·James H Hurley, Lindsey N Young
Jun 22, 2017·Trends in Plant Science·Marion ClavelPascal Genschik
Jan 3, 2018·Journal of Experimental Botany·Alexandre Y LearyTolga O Bozkurt
Feb 24, 2018·Journal of Experimental Botany·Tamar Avin-WittenbergHenri Batoko
Dec 21, 2017·Viruses·Zhenlong LiuBenoit Barbeau
May 8, 2018·Cells·Athanasios MetaxakisNektarios Tavernarakis
Dec 14, 2017·Essays in Biochemistry·Aurore Claude-TaupinVojo Deretic
Sep 6, 2017·Nature Microbiology·Konstantin M J SparrerMichaela U Gack
Oct 19, 2017·The Journal of Biological Chemistry·Atsuhiro AdachiYoshinori Ohsumi
Apr 20, 2018·The Journal of Clinical Investigation·Natalia Rodriguez-MuelaLee L Rubin
Sep 21, 2018·Antioxidants & Redox Signaling·Maroua FerhatSihem Boudina
May 5, 2018·Stroke; a Journal of Cerebral Circulation·Kyeong-A KimOk-Nam Bae
Feb 13, 2019·International Journal of Molecular Sciences·Maria CondelloStefania Meschini
Feb 15, 2019·The American Journal of Tropical Medicine and Hygiene·Bishwanath AcharyaKesara Na-Bangchang
Apr 17, 2019·Biological Reviews of the Cambridge Philosophical Society·Kewal K MahapatraSujit K Bhutia
Jul 5, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yunshan ChenHuishu Liu
Jun 10, 2017·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
Jan 19, 2018·The EMBO Journal·Gabriele ZaffagniniSascha Martens
Aug 10, 2019·Molecular Plant Pathology·Nirbhay Kumar KushwahaDaniel Hofius
Mar 19, 2020·International Journal of Molecular Sciences·Iswariyaraja Sridevi GurubaranKai Kaarniranta
Feb 20, 2020·Open Biology·Magdalena BüscherMatthias W Hentze
Jul 23, 2019·PLoS Biology·Erin K ZessYasin F Dagdas
May 22, 2020·The Journal of Cell Biology·Dorotea FracchiollaSascha Martens
Jun 10, 2020·The Journal of Cell Biology·Xiaoshan ShiJames H Hurley

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Methods Mentioned

BETA
ubiquitination
transfection
lipidation

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