Mechanisms of sepsis and insights from clinical trials.

Drug Discovery Today. Disease Mechanisms
Nitin Seam, Anthony F Suffredini

Abstract

Multiple clinical trials of adjunctive therapy for sepsis and septic shock have been conducted to neutralize bacterial components or to modulate host inflammatory responses to infection but with limited success. Many therapies are only beneficial only in patients with a high severity of illness and have minimal or harmful effects in patients that are less severely ill. Improved measures of severity of illness and discovery of biomarkers to help identify these high-risk patients are needed.

References

Apr 1, 1984·Annals of Internal Medicine·M M ParkerJ E Parrillo
Oct 21, 2000·Lancet·M van Deuren, P Brandtzaeg
Nov 4, 2000·Expert Opinion on Investigational Drugs·B D Freeman, C Natanson
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·R S Munford, J Pugin
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·B D FreemanC Natanson
Sep 1, 2001·The New England Journal of Medicine·D W Landry, J A Oliver
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Jeffrey J PresneillJohn W Wilson
Sep 27, 2002·The New England Journal of Medicine·Richard P Wenzel
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Jul 9, 2004·Annals of Internal Medicine·Peter C MinneciCharles Natanson
Mar 15, 2005·Chest·Bertrand GuidetUNKNOWN CUB-Réa Study Group
Apr 13, 2005·The Journal of Trauma·Katherine J DeansPeter C Minneci
Oct 11, 2005·Critical Care Medicine·Peter Q EichackerCharles Natanson
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Jan 21, 2006·Critical Care Medicine·Peter C MinneciPeter Q Eichacker
Sep 8, 2006·Intensive Care Medicine·Martin Fraser Clark, Simon Victor Baudouin
Feb 7, 2007·Annals of Internal Medicine·Alexis F TurgeonPaul C Hébert
Feb 28, 2007·Intensive Care Medicine·Peter Q Eichacker, Charles Natanson

❮ Previous
Next ❯

Citations

Jun 2, 2012·PLoS Pathogens·Santosh K PandaBalachandran Ravindran
Dec 23, 2010·Immunotherapy·Anastasia Antonopoulou, Evangelos J Giamarellos-Bourboulis
Nov 3, 2010·Acute Cardiac Care·Alexander Shpektor
Dec 17, 2009·British Journal of Pharmacology·Kenneth L BeckerEric S Nylen
Jan 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Omar A HarasstaniDaud A Israf
Sep 1, 2015·World Journal of Biological Chemistry·Klaus Brandenburg, Tobias Schürholz
Aug 1, 2013·Physiological Reviews·Kendra N IskanderDaniel G Remick
Oct 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Weng-Lang YangPing Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.