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Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy

Nucleic Acids Research

May 19, 2016

Ali A AlmaqwashiM Christian Williams

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Abstract

There is a wide range of applications for non-covalent DNA binding ligands, and optimization of such interactions requires detailed understanding of the binding mechanisms. One important class of these ligands is that of intercalators, which bind DNA by inserting aromatic moieties betwe...read more

Mentioned in this Paper

Small Molecule
Complex (molecular entity)
Helix (Snails)
Ligands
Study
Microscopy, Atomic Force
DNA Conformation
Covalent Interaction
Major Groove
DNA Binding
2
78
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Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy

Nucleic Acids Research

May 19, 2016

Ali A AlmaqwashiM Christian Williams

PMID: 27085806

DOI: 10.1093/nar/gkw237

Abstract

There is a wide range of applications for non-covalent DNA binding ligands, and optimization of such interactions requires detailed understanding of the binding mechanisms. One important class of these ligands is that of intercalators, which bind DNA by inserting aromatic moieties betwe...read more

Mentioned in this Paper

Small Molecule
Complex (molecular entity)
Helix (Snails)
Ligands
Study
2
78

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