Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex-Mouse Subplate Zone.

Cerebral Cortex
Mandakini B SinghSrdjan D Antic

Abstract

Subplate (SP) neurons exhibit spontaneous plateau depolarizations mediated by connexin hemichannels. Postnatal (P1-P6) mice show identical voltage pattern and drug-sensitivity as observed in slices from human fetal cortex; indicating that the mouse is a useful model for studying the cellular physiology of the developing neocortex. In mouse SP neurons, spontaneous plateau depolarizations were insensitive to blockers of: synaptic transmission (glutamatergic, GABAergic, or glycinergic), pannexins (probenecid), or calcium channels (mibefradil, verapamil, diltiazem); while highly sensitive to blockers of gap junctions (octanol), hemichannels (La3+, lindane, Gd3+), or glial metabolism (DLFC). Application of La3+ (100 μM) does not exert its effect on electrical activity by blocking calcium channels. Intracellular application of Gd3+ determined that Gd3+-sensitive pores (putative connexin hemichannels) reside on the membrane of SP neurons. Immunostaining of cortical sections (P1-P6) detected connexins 26, and 45 in neurons, but not connexins 32 and 36. Vimentin-positive glial cells were detected in the SP zone suggesting a potential physiological interaction between SP neurons and radial glia. SP spontaneous activity was reduced by blo...Continue Reading

References

Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Mar 1, 1995·Journal of Neurobiology·P Rakic, H Komuro
Nov 21, 1994·Brain Research·R A Swanson, S H Graham
Dec 29, 1998·The Journal of Biological Chemistry·S A JohnJ N Weiss
Dec 14, 1999·Neuron·D StellwagenM B Feller
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N C SpitzerT M Gomez
Oct 3, 2000·Journal of Molecular and Cellular Cardiology·R P KondoJ I Goldhaber
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jorge E ContrerasJuan C Sáez
Jan 16, 2002·The Journal of Biological Chemistry·Charles E StoutAndrew C Charles
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Oct 24, 2002·Journal of Neuroscience Methods·Harris RippsJane Zakevicius
Dec 4, 2002·Nature Reviews. Neuroscience·Anne E WestMichael E Greenberg
Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Daniel A Goodenough, David L Paul
Jul 26, 2003·Science·Patrick O KanoldCarla J Shatz
Dec 19, 2003·Journal of Neurophysiology·Mohsin Md SyedZ Jimmy Zhou
Jun 29, 2004·Trends in Neurosciences·Nicholas C SpitzerLaura N Borodinsky
Aug 7, 2004·The Journal of Physiology·Rebekah CorlewWilliam J Moody
Apr 23, 2005·The Journal of Physiology·Victoria F SafiulinaRashid Giniatullin
Sep 7, 2005·Brain Research. Molecular Brain Research·Angelika VogtHannah Monyer
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachael A PearsonPeter Mobbs
May 10, 2007·Journal of Neurochemistry·Ludmila A VolobouevaRona G Giffard
Jul 21, 2007·The Journal of Comparative Neurology·Cima CinaChristian C G Naus
Nov 2, 2007·Nature·Nicolas X TritschDwight E Bergles
Oct 14, 2008·Channels·Roger J Thompson, Brian A Macvicar
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Camille AllèneRosa Cossart
Dec 3, 2009·Nature Reviews. Neuroscience·Aaron G Blankenship, Marla B Feller
Mar 6, 2010·Annual Review of Neuroscience·Patrick O Kanold, Heiko J Luhmann
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahito KawamuraSusan A Masino
Oct 29, 2010·Journal of Anatomy·Gavin ClowryPasko Rakic
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna R MooreSrdjan D Antic

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Citations

Apr 9, 2020·Frontiers in Neuroanatomy·Chiaki Ohtaka-Maruyama
Nov 27, 2020·Brain & Development·Ana KatušićIvica Kostović
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Vera P Medvedeva, Alessandra Pierani
Jul 23, 2021·Neuron·Francisco J MartiniGuillermina López-Bendito

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