Mechanisms of sudden unexplained death in epilepsy

Current Opinion in Neurology
Alica M Goldman

Abstract

Human and experimental research has identified cardioautonomic and respiratory dysfunction as a frequent accompaniment in human and animal model events of sudden unexpected death in epilepsy (SUDEP). This review aims to provide an overview of the scientific evidence behind the currently accepted risk factors and working hypotheses regarding SUDEP pathophysiology. Epidemiological analysis of public health burden of SUDEP has shown that it rates second only to stroke in the years of potential life lost. Clinical and experimental studies uncovered the dynamic cardiorespiratory dysfunction interictally and imminently to SUDEP, and model systems have facilitated discoveries in SUDEP mechanistic understanding and application of pilot therapeutic interventions. Pilot molecular profiling of human SUDEP has uncovered complex genomic structure in the candidate gene network. Extensive clinical and experimental work has established a rationale for the conceptual thinking about SUDEP mechanisms. The application of the global molecular profiling will be invaluable in unraveling the individually unique genomic complexities and interactions that underlie the physiological signature of each patient. At the same time, sophisticated model systems...Continue Reading

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Citations

Jul 22, 2015·Expert Review of Neurotherapeutics·Huan LiaoXuefeng Wang
Apr 29, 2016·Neurology. Genetics·Magy AbdelwahabRaphael Schiffmann
Jul 12, 2016·Annals of Neurology·Josef Finsterer, Sinda Zarrouk-Mahjoub
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Jan 13, 2018·The Journal of Clinical Investigation·YuJaung KimGeorge B Richerson
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Oct 29, 2015·Current Opinion in Supportive and Palliative Care·David Hui
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Jun 21, 2019·Neurology·Chloe VerducciOrrin Devinsky
Sep 19, 2019·Epilepsy Currents·Rui Li, Gordon F Buchanan
Feb 1, 2020·BMC Cardiovascular Disorders·Jörg ReifartAndreas Hain
Feb 19, 2021·Epilepsia·Edward BeamerTobias Engel
Mar 21, 2021·Epilepsy & Behavior : E&B·Marina TrivisanoFrancesca Bisulli

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