PMID: 9184787May 1, 1997Paper

Mechanisms of surfactant dysfunction in early acute lung injury

Experimental Lung Research
M KennedyE Ingenito

Abstract

Surfactant dysfunction that occurs during acute lung injury is associated with alterations in phospholipid, total protein, and surfactant apoprotein content. The functional importance of these changes was examined by characterizing the biophysical properties and biochemical composition of lung surfactant from endotoxin-treated guinea pigs (LPS) with acute lung injury. Static and dynamic lung compliance significantly decreased following endotoxin exposure. Lavage fluid demonstrated a neutrophil predominance, and tissue histopathology revealed inflammation consistent with acute lung injury. LPS surfactant isolated by ultracentrifugation had minimum surface tensions of 21 dynes/cm compared to 2 dynes/cm among control samples. Biochemical abnormalities in LPS surfactant included increased total protein, decreased phosphatidylcholine, and increased sphingomyelin, phosphatidylethanolamine, and lysophosphatidylcholine. The addition to normal guinea pig surfactant of butanol extracts precipitated from lavage fluid of LPS animals and containing known amounts of protein caused elevations in minimum surface tensions to > or = 20 dynes/cm at protein to phospholipid ratios equivalent to those observed in LPS surfactant pellets. Addition of ...Continue Reading

References

Mar 11, 1992·Experimental Lung Research·B M AndersonW J Longmore
Jun 1, 1992·The American Review of Respiratory Disease·R HiguchiM Ikegami
Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
May 1, 1991·Journal of Applied Physiology·F H GreenM Prior
Jul 1, 1991·American Journal of Respiratory Cell and Molecular Biology·M C WilliamsR L Hamilton
Jul 1, 1991·Journal of Applied Physiology·B A HolmG Enhorning
May 1, 1991·The American Review of Respiratory Disease·S K Leeper-WoodfordA A Fowler
Oct 1, 1990·Physiological Reviews·D Stamenović
May 22, 1990·Biochimica Et Biophysica Acta·N J Gross, R M Schultz
Jun 1, 1989·Canadian Journal of Physiology and Pharmacology·K M KeoughM G Tweeddale
Dec 1, 1989·The Journal of Trauma·J J LiJ F Burke
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Jul 1, 1989·The American Review of Respiratory Disease·Y SuzukiK Kogishi
Aug 1, 1988·The American Review of Respiratory Disease·A IshizakaT A Raffin
Nov 1, 1988·Chemistry and Physics of Lipids·B A HolmR H Notter
Oct 1, 1987·Journal of Applied Physiology·B A Holm, R H Notter
Nov 1, 1985·Journal of Applied Physiology·B A HolmS Matalon
Dec 1, 1994·Journal of Applied Physiology·E P IngenitoB Davison
Dec 1, 1993·Journal of Applied Physiology·E P IngenitoJ J Fredberg
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·S B HallR H Notter
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·T UedaA Jobe
Dec 1, 1993·The American Journal of Physiology·S A RooneyD S Phelps
Jan 1, 1993·The American Review of Respiratory Disease·J F Lewis, A H Jobe
Mar 1, 1993·Journal of Applied Physiology·J J FredbergS A Shore

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Citations

Feb 26, 2004·Paediatric Respiratory Reviews·Neil N Finer
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·E P IngenitoL Mark
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·K W LuJ A Clements
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Karan S Bhalla, Rodney J Folz
May 3, 2011·American Journal of Respiratory and Critical Care Medicine·Angela Panoskaltsis-MortariUNKNOWN American Thoracic Society Committee on Idiopathic Pneumonia Syndrome
Jun 5, 2002·American Journal of Respiratory and Critical Care Medicine·Kate G DavidsonIan R Doyle
Jul 27, 2001·American Journal of Respiratory Cell and Molecular Biology·E P IngenitoL A Sonna
Jul 23, 2004·American Journal of Respiratory Cell and Molecular Biology
Apr 25, 2014·Critical Care Medicine·Tyler J WellmanMarcos F Vidal Melo
Jul 22, 2015·PloS One·Marios-Angelos MouratisVassilis Aidinis
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Matthias OchsJoachim Richter
Aug 5, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·R MoraE P Ingenito

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